Pirfenidone Delays PAH Progression in Rodent Model
Pirfenidone improves pulmonary hemodynamics and vascular remodeling in a rat model of pulmonary arterial hypertension (PAH), a new study published in Pulmonary Circulation found. The study also found that the treatment decreased the cleavage of IL-1β and IL-18, which are products of the activation of NLRP3 inflammasome and play key roles downstream from NLRP3. The…