A ‘Cold’ Experiment That Has This CAD Patient Thinking
Since I was diagnosed with CAD, I have wondered what would happen if I was in an emergency situation.
Diagnosis & Disease Information
Case Report Highlights Coexisting Myasthenia Gravis and Achalasia
Myasthenia gravis (MG) and achalasia could coexist at the same time, according to a study recently published in the Egyptian Journal of Neurology, Psychiatry and Neurosurgery. “In addition, it has raised neurologists’ knowledge and awareness of achalasia in patients of MG complaining of recurrent vomiting and dysphagia resistant to standard therapy, which includes thymectomy and rapid…
Identifying Genetic Variants of AIRE Associated With Immune Thrombocytopenia
Specific genetic variants of the autoimmune regulator (AIRE) gene could be associated with immune thrombocytopenia (ITP), according to a study recently published in the International Journal of Molecular Sciences. “Our findings reveal that the AIRE rs2075876 genetic variants (AA genotype and A allele) and A–A haplotype are associated with increased ITP risk in the Egyptian population…
Fatigue in AAV May Meet Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
A sizeable portion of individuals with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) experience fatigue severe enough to meet the diagnostic criteria for myalgic encephalomyelitis/chronic fatigue syndrome, according to a study published in The Lancet Regional Health — Americas. The authors of this study sought to assess fatigue in patients with AAV to see if it…
A Case of AAV With Gastrointestinal System Involvement
A patient with granulomatosis with polyangiitis, a form of antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), received long-term multidisciplinary treatment at an intensive care unit (ICU) due to massive hemorrhage and multisystem involvement, according to an article published in the Turkish Journal of Trauma and Emergency Surgery. The study authors reported on a 37-year-old male patient…
Higher Mortality and Infection Rates Seen in Patients With AAV and ESKD
In patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and end-stage kidney disease (ESKD) who are receiving renal replacement therapy, higher rates of mortality and infection have been reported, along with a lower risk for relapse, according to findings from a meta-analysis published in Seminars in Arthritis and Rheumatism. Approximately 20% of patients with AAV…
CanVasc Publishes Updated Recommendations for Avacopan Use in AAV
The Canadian Vasculitis Research Network (CanVasc) has updated its consensus recommendations for the use of avacopan in patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). The guidelines, published in Rheumatology, are based on data confirming that avacopan is an effective steroid-sparing therapy for microscopic polyangiitis and granulomatosis with polyangiitis. “Prospective studies published between 2017 and…
New Study Set to Assess Povetacicept in Adults With CAD and Other Cytopenias
Alpine Immune Sciences is launching a new study to evaluate povetacicept (ALPN-303) in adults with autoimmune cytopenias including immune thrombocytopenia, warm autoimmune hemolytic anemia, and cold agglutinin disease (CAD). The study, listed on ClinicalTrials.gov, aims to determine whether povetacicept is safe and potentially effective for treating these conditions. CAD is a rare autoimmune disease characterized…
Chronic Kidney Disease Represents a Significant Burden for Patients With AAV
A new study has identified 4 renal function trajectories in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), with over half of patients affected by renal manifestations. The study, published in Arthritis Care & Research, highlights the burden of chronic kidney disease (CKD) in this patient population. “Renal manifestations of AAV span a range of…
Study Reveals Elevated NET Levels in Patients With ANCA-Associated Vasculitis
Patients with subtypes of small-vessel antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), including granulomatosis with polyangiitis and microscopic polyangiitis, as well as those with certain types of large-vessel vasculitis (LVV), may have elevated circulating levels of neutrophil-activating factors, according to an article published in Clinical Immunology. In this study, the researchers primarily assessed the levels of…
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