Researchers from China built a combined model to predict the likelihood of liver metastasis in high-risk gastrointestinal stromal tumors (GISTs). “Texture features from [volumes of interest] on portal venous phase [computed tomography (CT)] images have the value of effectively predicting liver metastasis of high-risk GISTs noninvasively, and further incremental discriminative value was verified when it…
Mitotic rates and tumor sizes were found to be significant prognostic factors for the progression of gastrointestinal stromal tumors (GISTs) located in the colon or esophagus, according to a new study. Tumors in these locations that were larger than 5 cm and tumors with greater than 5 mitoses per 5 mm2 (5/5mm2) had hazard ratios…
A small trial showed that selpercatinib (LOXO-292) is effective in the treatment of medullary thyroid carcinoma (MTC) in children with multiple endocrine neoplasia type 2 (MEN2) and resulted in clinical, biochemical, and radiological improvements. Results were published in the European Journal of Cancer. By the third month of treatment with selpercatinib, all children (n=6) had…
A 34-year-old female was diagnosed with a gastrointestinal stromal tumor (GIST) and renal clear cell carcinoma (RCC) during pregnancy, according to a report published in the journal Urology Case Reports. The patient experienced persistent dyspepsia during her second trimester of pregnancy, which did not resolve with medication. On ultrasound examination, she showed abnormal renal and…
Adding durvalumab (Imfinzi®) to chemotherapy significantly improves overall survival in patients with advanced biliary tract cancer, according to interim results from a phase 3 clinical trial called TOPAZ-1. The dual treatment also improved progression-free survival and overall response rate. The combination was well-tolerated, and the discontinuation rate due to adverse events was not higher than…
The expression of dual-specificity phosphatase 11 (DUSP11) is associated with tumor infiltration and overall survival rate in intrahepatic cholangiocarcinoma, according to a new study published in Frontiers in Oncology. This was not the case for perihilar or distal cholangiocarcinoma. The researchers summarized that DUSP11 is an independent biomarker of intrahepatic cholangiocarcinoma that is indicative of…
A lower daily dose of 60 mg cabozantinib (Cometriq®) for the treatment of medullary thyroid cancer (MTC) failed to meet the primary endpoint of phase 4 EXAMINER clinical trial (NCT01896479). The results of the trial were presented at the 90th Annual Meeting of the American Thyroid Association. In the trial, patients were randomized 1:1 to…
The bromodomain-containing protein 9 (BRD9) was identified as a key molecule in the progression of gastrointestinal stromal tumors (GISTs), according to researchers from the Hospital of Jilin University, Changchun, China. The study was published in the journal Cell Death & Disease. BRD9 inhibition can be considered as a new therapeutic strategy in GISTs, used as…
A new retrospective study emphasized the importance of preoperative evaluation and frequent postoperative follow-up of gastrointestinal stromal tumor (GIST) patients. This study was published in the journal Medical Science Monitor. This close monitoring is particularly important in older male patients and patients with malignant comorbidities. “There is an association between tumor location, size, length of…
Dithiazanine iodide is an antiparasitic compound that has anticancer properties in vitro and is associated with decreased mitochondrial electron transport protein expression, as well as cellular ATP depletion in cholangiocarcinoma cells, according to a poster being presented at the NORD Breakthrough Summit 2021. These results support the potential use of the compound as a therapy…
