Radiologists

Study Finds Laparoscopy-Assisted Resection Safe for Large GISTs

Laparascopy-assisted surgery (LAS) was both feasible and safe for patients with gastrointestinal stromal tumors (GISTs) larger than 5 cm, particularly in the hands of experienced surgeons, according to a study published in Surgery. The researchers reported improved short-term outcomes and similar oncological results irrespective of the location of the resected tumor. “Whether laparoscopy-assisted treatment of…

cancer cell

Novel Risk Table Predicts Metastasis in MTC Study

Demographical, clinical, and tumor characteristics may predict the risk of metastasis in patients with medullary thyroid carcinoma (MTC), according to a study recently published in Endocrine Pathology. “Our risk table can be an adjuvant tool in the interpretation of tumor aggressiveness by using basic clinical information,” the authors wrote. This scoring system consists of a…

calcitonin

Elevated Preoperative Calcitonin Predicts Poor Outcomes in MTC

Elevated levels of serum calcitonin predicted poor clinical outcomes in medullary thyroid carcinoma (MTC), according to a new study published in the Annals of Translational Medicine. The researchers found that serum calcitonin levels were positively correlated with tumor/node/metastasis (TNM) stage. “We found preoperative serum [calcitonin] levels could be potentially used as an important parameter to…

MRI of human brain

Structural and Functional Brain Alterations Linked With Fatigue in NMOSD

Structural and functional changes in the brain observed through magnetic resonance imaging (MRI) have been linked to fatigue in patients with neuromyelitis optica spectrum disorder (NMOSD), according to a study published in BMC Neurology. Changes in the volume of the bilateral pallidum and left nucleus accumbens were observed between low fatigue and high fatigue in…

research

Study Identifies Independent Prognostic Factors in GIST

Researchers in China identified independent prognostic indicators for gastrointestinal stromal tumors (GISTs) and published their findings in Medicine. This knowledge may improve accurate risk assessments and allow the use of individualized therapies and better follow-up strategies for patients. There are many factors affecting the prognosis of GISTs but the main ones are the tumor stage…

endoscopy

Mucosal Incision-Assisted Biopsy Safe for GIST, Study Finds

Researchers reported that mucosal incision-assisted biopsy for the sampling of gastric subepithelial lesions is safe, with minimal impact on postoperative prognosis, as published in Surgical Endoscopy. Gastrointestinal stromal tumors (GISTs) are the most common gastric subepithelial lesions. Because of the malignant potential of GISTs, it is important to distinguish them from other (benign) subepithelial lesions.…

Stem Cell Research Pipette

Four Genes Linked With iCCA Effective in Predicting Prognosis

Innovative use of genes as biomarkers for intrahepatic cholangiocarcinoma (iCCA) could determine response to chemotherapy, according to an article recently published in Stem Cell Research & Therapy. “We discovered that 4-key-genes are associated with self-renewal ability of [iCCA] and their overexpression could enhance chemoresistance of cholangiocarcinoma cells,” the authors wrote. This experimental research found that…

gene

Multigene Model Improves Prediction of CCA Recurrence

A molecular signature of 8-immune-related differentially expressed genes (8-IRDEGs) is a promising biomarker that can help distinguish the prognosis and molecular and immune features of cholangiocarcinoma (CCA), according to a new study published in Frontiers in Oncology. It can also help individualize immunotherapy for patients. Immune cell infiltration and mRNA expression are factors associated with…

chemotherapy

BRCAness Phenotype Indicates Favorable Progression-Free Survival in CCA Study

Patients with biliary tract cancers such as cholangiocarcinoma (CCA) who have the BRCAness phenotype have better progression-free survival after exposure to platinum-based chemotherapy, according to a new study published in the European Journal of Cancer. In addition, the trends of overall survival curves suggest that BRCAness patients “could benefit from a maintenance therapy with PARPi,”…

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