Hemithyroidectomy seems to be equally beneficial and safer than total thyroidectomy for unilateral medullary thyroid carcinoma (MTC), according to a study recently published in Langerbeck’s Archives of Surgery. “For patients with unilateral [sporadic MTC], hemithyroidectomy was adequate as a locally curative surgery, because the patients underwent total thyroidectomy did not benefit more from it in…
The use of somatostatin receptor (SSTR) positron emission tomography/computed tomography (PET/CT) is better than computed tomography alone in terms of assisting with therapeutic decision-making in patients with medullary thyroid carcinoma (MTC), according to a new study published in Endocrine. The researchers reported switching between surgery and systemic treatment with tyrosine kinase inhibitors (TKIs) in over…
The effectiveness and role of radiotherapy for patients with gastrointestinal stromal tumors (GISTs) may need to be reevaluated, according to findings that were recently published in Cancers. GISTs are believed to be resistant to radiotherapy and their use is primarily for palliative care. However, because patients with GISTs are expected to live longer compared with…
Intraoperative revision of margins from frozen sections could increase overall survival (OS) in patients with perihilar cholangiocarcinoma (CCA), according to a study recently published in Annals of Surgical Oncology. “Achieving a margin-negative resection (R0) is challenging given the anatomic location of tumors and remains the most important prognostic indicator of long-term survival,” the authors wrote.…
Gastrointestinal stromal tumors (GISTs) may sometimes manifest as gynecologic diseases in some patients, according to a case series published in Diagnostics. In the series, 20 different patients had masses or symptoms indicative of possible gynecological disease. A pelvic mass and/or abdominal pain was present in 18 patients and the other 2 had either a rectovaginal…
Cannabidiol (CBD) and cannabigerol (CBG) have antitumor activity on cholangiocarcinoma (CCA) in vitro, according to a new study published in Biomolecules. The researchers found that each compound uses a distinct cell death pathway to inhibit CCA. “We found that both CBD and CBG were effective in inhibiting cholangiocarcinoma cells in vitro in a dose-dependent manner,…
Researchers from China identified methylated-differentially expressed genes and signaling pathways that are significantly associated with cholangiocarcinoma (CCA) using a series of bioinformatics databases and tools and published their findings in Medicine. They also found 2 genes MYC and VWF that are hub genes, which possess potential predictive and prognostic value and therefore could be used…
Researchers discovered the radiological features and mucin (MUC) immunohistochemical expression patterns of a recent case of amphicrine medullary thyroid carcinoma (MTC) and published their results in Endocrine Pathology. Intra- and extracellular MUC production has been variably documented in benign and malignant thyroid tumors. While the expression and contribution of MUC1 have been significantly studied in…
Broader screening for pathogenic or likely pathogenic variants associated with endocrine tumor syndromes allows the detection of people at risk of developing the diseases, according to a new study published in BMC Medicine. Screening also results in the uptake of risk management and facilitates relevant diagnoses. “Further research will be necessary to continue to determine…
Asymptomatic optic nerve enhancement between optic neuritis (ON) attacks occurs predominantly at the site of previous lesions in 17% of patients with aquaporin-4 (AQP4) immunoglobulin G (IgG) neuromyelitis optica spectrum disorder (NMOSD), according to findings published in Neurology. Researchers conducted a retrospective cohort study from 2009 to 2019 at Mayo Clinic to assess optic nerve…
