physiatrists

Demyelinated nerve

New Study to Identify Biomarkers in MS Lesions Now Enrolling Patients

Rune Labs is enrolling patients with multiple sclerosis (MS) in a study that aims to identify neurophysiological biomarkers of the disease, according to a press release from the company. During the study, demyelination, a hallmark symptom of MS, will be measured using a closed loop technology. “By taking advantage of access to the spinal cord…

EMA Accepts Marketing Authorization of Natalizumab Biosimilar for MS

Polpharma Biologics of Amsterdam, Netherlands, an international biotech company, announced that the European Medicines Agency (EMA) accepted a Marketing Authorization Application (MAA) for biosimilar natalizumab, a monoclonal antibody treatment for adults with highly active relapsing-remitting multiple sclerosis (RRMS). Natalizumab is a proposed biosimilar to Tysabri®, and the application was for intravenous administration at the same…

MRI of human brain

Structural and Functional Brain Alterations Linked With Fatigue in NMOSD

Structural and functional changes in the brain observed through magnetic resonance imaging (MRI) have been linked to fatigue in patients with neuromyelitis optica spectrum disorder (NMOSD), according to a study published in BMC Neurology. Changes in the volume of the bilateral pallidum and left nucleus accumbens were observed between low fatigue and high fatigue in…

Pregnancy Associated With NMOSD Relapse in Younger Patients

Researchers explored the association between pregnancy and the development and course of neuromyelitis optica spectrum disorder (NMOSD) in women of childbearing age and published their findings in Clinical Neurology and Neurosurgery. They found no effect of pregnancy prior to disease onset, however, in younger patients, pregnancy might be a trigger for the onset of NMOSD…

New Blood Test Predicts Disease Progression in MS

Neurofilament light chain (NfL) is a new and easily accessible blood test that could predict disease progressions of several neurodegenerative diseases, such as multiple sclerosis (MS), Parkinson’s disease, and Alzheimer’s Disease, according to a recent press release by LabCorp. The principle behind the test is that Neurofilament release is a known consequence of neuronal destruction.…

neutrophil

Purinergic Inhibitors Disrupt Complement Activation in NMOSD Model

Purinergic2 receptors (P2Rs) may play a key role in the pathophysiology of neuromyelitis optica spectrum disorder (NMOSD), suggesting this process as a potential therapeutic target, according to a study recently published in Neurotherapeutics. “This mechanism is of relevance for the use of purinergic inhibitors in ex vivo and in vivo models of autoimmunity and may…

exercise equipment

Study Identifies Lifestyle Factors Related to Disease Progression in MS

A variety of lifestyle factors are correlated with disability progression in patients with multiple sclerosis (MS), according to a study published in Multiple Sclerosis and Related Disorders. The researchers found that lifestyle factors including physical activity, arterial hypertension, being overweight/obese, the use of lipid-lowering drugs, and cognitive reserve were all related to the accumulation of…

Plasmapheresis as an Effective Therapy for NMOSD, MS, and MG

Patients with neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS), and myasthenia gravis (MG) showed significant improvements after treatment with plasmapheresis, according to results from the Japan-Plasmapheresis Outcome and Practice Patterns Study published in Therapeutic Apheresis and Dialysis. Statistically significant improvements in the modified Rankin Scale (mRS) and Barthel Index scores were reported for patients…

test tube

IL-6 Levels Correlate With NMOSD Relapse Severity

Researchers found a correlation between serum levels of longitudinal interleukin (IL)-6 in patients with neuromyelitis optica spectrum disorder (NMOSD) with disease activity and brain volume, as published in the Journal of Neuroimmunology. They specifically found increased IL-6 serum levels during NMOSD relapses. “To investigate whether IL-6 can be used as a marker for disease activity,…

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