insulin molecule

Newly Identified Metabolites Aid in Early Detection of MTC

Three metabolites could help differentiate patients with medullary thyroid carcinoma (MTC) from healthy individuals, according to a new study published in Scientific Reports. These are linoleic acid, linolenic acid, and leucine, and they can potentially be used as tumor biomarkers for the early detection of MTC. The metabolites were identified through the metabolomics profiling of…

thyroid cancer

MTC With Cushing’s Syndrome Successfully Treated With Selpercatinib

A new case report demonstrates success in employing selpercatinib to treat a 62-year-old man with ectopic Cushing’s syndrome due to medullary thyroid carcinoma (MTC). The case report, published in Current Oncology, notes that the patient’s Cushing’s features had resolved after 6 months of treatment. After another 6 months, his s-calcitonin had normalized and there was…

Ultrasound detail

Radiomics Features Differentiate MTC From PTC Nodules

Different radiomics features can help differentiate between medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) nodules of different sizes, according to a new study published in Clinical Medicine Insights: Oncology. Analyzing different combinations of radiomics features can lead to better diagnostic efficiency compared to single radiomics features and is a more reliable approach for…

genetic testing

Novel Genetic Profile Identified in Case of Systemic Mastocytosis

A novel genotype was identified in a patient with systemic mastocytosis (SM) and published in a case report in Cancer Genetics. “This case provides evidence that MCL [mast cell leukemia] can have wide spectrum of genetic abnormalities as well as accumulation of mutations in various genes including BRAF,” the authors said. The study demonstrated coexistent…

thyroid cancer cells

Lactic Acidosis Promotes Aggressive Features in Cholangiocarcinoma

Researchers found an increase in cancer aggressiveness in cholangiocarcinoma (CCA) cells exposed to lactic acidosis due to the upregulation of ALDH1A3, as published in Life Sciences. The team derived information on ALDH1A3 expression in CCA cells from the Gene Expression Omnibus datasets. They also used several human CCA cell lines to demonstrate increased ALDH1A3 expression…


Researchers Identify Drug-Drug Interactions of Ripretinib for GISTs

Dose adjustments are not necessary for patients with gastrointestinal stromal tumors (GISTs) when they are given ripretinib with gastric acid reducers and strong CYP3A inhibitors, according to a study published in Clinical Pharmacology in Drug Development. The researchers assessed the drug-drug interaction potentials of ripretinib with 3 other drugs: itraconazole, rifampin, and pantoprazole. They said that…

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