Nephrologists

antibody measurements

Study Validates Banff Criteria for Acute AMR After Liver Transplant

Researchers reported that a good correlation between donor specific antibody, histology, and C4d staining results validates the Banff criteria for acute antibody-mediated rejection in patients who have undergone liver transplantation, as published in Human Pathology. The Banff Working Group published guidance in 2016 with the goal of standardizing the diagnostic criteria for antibody-mediated rejection in…

BMI calculator

Maralixibat Linked With Height and Weight Catch-Up in ALGS

Maralixibat treatment leads to height and weight catch-up in patients with Alagille syndrome (ALGS), according to a new study presented at the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) 54th annual meeting. “Patients with the greatest height disadvantage at baseline had the greatest catch-up in height,” the authors of the study said. Maralixibat…

leukocytes

Telomere Length Associated With Cardiovascular Risk in Pediatric ALGS

Shorter leukocyte telomere length in pediatric patients who have undergone liver transplantation for conditions such as Alagille syndrome (ALGS) tends to be associated with higher intima-media thickness and aspartate aminotransferase, according to an article published in Liver Transplantation. These results suggest that early biological aging may contribute to subclinical cardiovascular damage and could affect the…

Guidelines

A New Consensus on Managing Liver Cirrhosis Complications in Children

A group of experts recently gathered to produce a consensus on the appropriate management of complications related to liver cirrhosis (LC) in children; the resulting guideline was published in the Journal of Mexican Gastroenterology.  The causes of LC in childhood are varied, ranging from genetic disorders such as Alagille syndrome to viral infections like hepatitis…

serum vials

IL-31 Levels Correlate With Cholestatic Disease, ALGS

IL-31 serum levels correlate with pruritus and may be a useful biomarker for studies investigating therapies in patients with cholestatic diseases such as Alagille syndrome (ALGS), according to a new study published in Hepatology. Levels of IL-31 were found to be elevated in patients with other cholestatic diseases including primary sclerosing cholangitis (PSC) and primary…

doctor notes

Maralixibat Linked With Improved Quality of Life in ALGS

Maralixibat treatment leads to marked improvements in pruritus and quality of life in patients with Alagille syndrome (ALGS), according to a study published in Hepatology Communications.  The finding is based on results from 2 randomized placebo-controlled clinical trials investigating the effect of maralixibat in 57 children with severe cholestasis secondary to ALGS. Maralixibat, marketed under…

liver disease

Targeting Bile Acid Signaling Shows Therapeutic Potential in ALGS

Researchers discovered that therapies targeting the signaling of bile acids represent a promising and effective strategy to treat complex liver disorders, as published in Biomedicine & Pharmacotherapy.  The incidence of liver disease has risen sharply over the last few years. Liver disease encompasses a wide range of diagnoses, from nonalcoholic fatty liver disease to hepatitis…

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