immunologists

intravenous medication

Trial Testing HAE Drug Candidate Terminated

A phase 2 clinical trial known as KOMPLETE, testing the investigational hereditary angioedema (HAE) treatment KVD824, has been terminated, according to KalVista Pharmaceuticals, the developers of the treatment. This is because of an increase in liver enzymes (ALT/AST) in many patients receiving the treatment. “The health and safety of participants in our clinical trials is…

blood and serum

Individualized Reference Ranges for Serum Tryptase Useful for Diagnosing SM

A new study has demonstrated the utility of establishing individualized reference ranges for baseline serum tryptase (BST) levels in the diagnosis and management of people with systemic mastocytosis (SM) and other myeloid neoplasms. The study, published in Blood Advances, developed a model of BST levels based on the hereditary trait alpha-tryptasemia (HαT), which is caused…

Clinical Trial

Organ Damage Pattern in Advanced SM Could Aid Clinical Trial Patient Selection

The patterns of organ damage in advanced systemic mastocytosis (SM) are associated with the type of disease, prior treatment, and mutation profile, according to a new study published in the journal Clinical Lymphoma Myeloma and Leukemia. These findings can help clinicians decide which patients with advanced SM to enroll in clinical trials, the authors said.…

pregnant woman

Misdiagnosis of HAE Is Common During Pregnancy, but Successful Delivery Is Possible

A new case report illustrates the challenges of diagnosing hereditary angioedema (HAE), particularly during pregnancy, but also shows that pregnancy and delivery can be successfully managed in these cases. The report, published in the Canadian Medical Association Journal, suggests that patient management should include collaboration with specialists in HAE as well as treatment with plasma-derived…

Human microbiota

HAE Attack Severity Associated With Alterations in Throat Microbiota

A new study has shed light on hereditary angioedema (HAE)-associated throat microbiota and found a correlation between attack severity and microbial flora. “The associations between throat microbiomes with laryngeal edema and disease severity in HAE patients may indicate the potential of microbiome-based interventions in the prevention and treatment of HAE episodes,” the study authors said.…

patients with covid-19 in hospital

Case Report: Patient With Hereditary Angioedema Dies After COVID-19 Infection

Researchers presented a case report in Cureus of a patient with hereditary angioedema who died shortly after contracting coronavirus disease 2019 (COVID-19). Hereditary angioedema is characterized by recurrent swelling via bradykinin or dysregulation of the histaminergic response. This then causes the inflammatory cascade to proceed unchecked, giving rise to vasodilation and vascular permeability, the very…

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