Hepatologists

surgery

Liver Transplant Survival Rates Similar Between ALGS and Biliary Atresia Patients

Patient survival and graft survival rates following liver transplantation are similar between patients with Alagille syndrome (ALGS) and those with biliary atresia, according to a new study published in the Journal of Pediatric Gastroenterology and Nutrition. This is the case despite higher congenital heart defect and cardiac intervention rates, creatinine levels, and model for end-stage…

Molecular Genetic Testing: An Important Component in Diagnosing ALGS

Researchers identified a previously classified “idiopathic” gene that is responsible for neonatal/infantile cholestasis, including in patients with Alagille syndrome (ALGS), and presented their results at the 54th annual European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) meeting. The study credits advances in molecular genetics, particularly the use of next-generation sequencing in testing candidate genes…

surgery

Data Support Intraoperative Revision of Biliary Margins in CCA

Intraoperative revision of margins from frozen sections could increase overall survival (OS) in patients with perihilar cholangiocarcinoma (CCA), according to a study recently published in Annals of Surgical Oncology. “Achieving a margin-negative resection (R0) is challenging given the anatomic location of tumors and remains the most important prognostic indicator of long-term survival,” the authors wrote.…

Cannabidiol

Cannabidiol and Cannabigerol Effectively Inhibit CCA Cells

Cannabidiol (CBD) and cannabigerol (CBG) have antitumor activity on cholangiocarcinoma (CCA) in vitro, according to a new study published in Biomolecules. The researchers found that each compound uses a distinct cell death pathway to inhibit CCA. “We found that both CBD and CBG were effective in inhibiting cholangiocarcinoma cells in vitro in a dose-dependent manner,…

Newly Identified Hub Genes as Methylation-Based Biomarkers in CCA

Researchers from China identified methylated-differentially expressed genes and signaling pathways that are significantly associated with cholangiocarcinoma (CCA) using a series of bioinformatics databases and tools and published their findings in Medicine. They also found 2 genes MYC and VWF that are hub genes, which possess potential predictive and prognostic value and therefore could be used…

DNA genetics

New Capsid Selection Strategy Could Benefit Gene Therapy Development for LAL-D

Researchers at Homology Medicines developed a capsid selection strategy that can allow the use of the best vector to develop gene therapies to treat different genetic diseases including lysosomal storage disorders such as lysosomal acid lipase deficiency (LAL-D). This approach, the researchers said allows them to “embrace a capsid selection rather than a ‘one-capsid-fits-all’ limitation…

Study Elucidates Pathogenesis of Z-AAT-Associated Lung Disease

Researchers identified a mechanism that may be responsible for the toxic gain of function of Z-AAT, the most common form of alpha-1 antitrypsin (AAT) causing AAT deficiency (AATD), and published their results in JCI Insights. “The findings of this study will contribute to elucidating more details in the pathogenesis of Z-AAT-associated lung diseases,” they wrote.…

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