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SCD Independently Associated With Impaired Cognitive Function

Sickle cell disease (SCD) is known to be associated with a higher prevalence of sensorineural hearing loss (SNHL) and poor school performance compared to hemoglobin AA carriers, increasing the risk for cognitive impairment in these patients. Nonetheless, hearing impairment in the absence of SCD is also negatively associated with learning-related cognitive functions, leaving the association…

Newly Identified ICU Characteristics May Help Reduce Mortality in CAD

Researchers reported the characteristics and outcomes of adult patients with severe autoimmune hemolytic anemia (AIHA) admitted to the intensive care unit (ICU), as presented at the 63rd American Society for Hematology Annual Meeting & Exposition. AIHA is known to carry a poor prognosis and studies have indicated that the overall mortality rate is between 8% to…

Study Suggests COVID-19 Could Exacerbate CAD

Researchers presented the case of an 83-year old woman with secondary cold agglutinin disease (CAD) whose disease worsened due to a COVID-19 infection, as published in Cureus. “Association between COVID-19 and [cold agglutinin syndrome] is a recent and novel finding,” Yash V. Bhagat and the coauthors of the study wrote. “The lack of established evidence-based…

Researchers Emphasize Clinical and Immunohematology Testing for CAD

A patient was diagnosed with cold agglutinin syndrome (CAS) after the discovery of cold-antibody autoimmune hemolytic anemia (cAIHA) and splenic marginal zone lymphoma (MZL), as published in Hematology, Transfusion and Cell Therapy. CAS was recently described as a separate but similar entity to cold agglutinin disease (CAD). “In [CAD], patients may have a B-cell clonal…

Switching to BAY 81-8973 Could Help Optimize Hemophilia Treatment

Patients with hemophilia A who switched to BAY 81-8973 (octocog alfa; Kovaltry®) from other standard half-life (SHL) factor VIII (FVIII) products maintained already favorable outcome rates with a possible improvement in half-life, as published in Haemophilia. The patients enrolled in the study had a median annualized bleeding rate (ABR) and annualized joint bleeding rate (AJBR)…

Patients With Hemophilia Often Given Potentially Inappropriate Medications

The exposure to potentially inappropriate medications is higher among older patients with hemophilia and von Willebrand disease than the general population of older individuals, according to the results of a multicentre prospective observational study called M’HEMORRH-AGE. “Interventions focusing on deprescription of these inappropriate medications should be conducted in this specific population,” the authors said in…

Routine Spirometry for Adults With SCD May Mitigate Decline

The annual decline in lung function is similar between sickle cell disease and cystic fibrosis, according to a new study published in Blood Advances. These findings support the importance of routine spirometry evaluation in adults with sickle cell disease. Even though there are no known therapies to stop the decline or increase lung function in adult…

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