hematologists

thrombosis

Direct Oral Anticoagulants as an Alternative Treatment for SCD

Direct oral anticoagulants compare favorably with vitamin K antagonists in lowering bleeding rates in patients with sickle cell disease (SCD), according to a study published in Blood Advances. A major complication of SCD is the risk of venous thromboembolism, which is associated with a higher risk of mortality. Scientists have discovered that all 3 components…

Stroke

Prophylactic Hydroxyurea Linked With Reduced Stroke Risk in SCD

Prophylactic use of hydroxyurea in children with sickle cell disease (SCD) significantly reduces middle cerebral artery blood velocity as assessed by transcranial doppler ultrasound (TCD), thus potentially reducing stroke risk in these patients, as published in the Journal of Clinical Medicine. The researchers provided further evidence supporting the use of hydroxyurea in patients with SCD,…

sickle cell disease

Proposed Genome Editing Technology Aims to Transform SCD Treatment

Precision BioSciences will use their novel genome editing technology called ARCUS® to develop a potentially curative treatment for sickle cell disease (SCD) and other hemoglobinopathies in collaboration with Novartis Pharma. The technology will use a custom nuclease to insert, in vivo, a therapeutic transgene at a “safe harbor” location in the genome. “We believe that…

blood research

Researchers Propose New Tiered Response Criteria for SM

Investigators from the European Competence Network on Mastocytosis and the American Initiative on Mast Cell Diseases have proposed refined response criteria for patients with advanced systemic mastocytosis (AdvSM). The updated response criteria utilizes a tiered approach including pathologic, molecular and cytogenetic, clinical, and symptom/quality of life responses, as published in the Journal of Allergy and…

dendritic cell

Monocyte and Dendritic Cell Abnormalities Correlate With SM

Innate immune cells such as dendritic cells and monocytes may contribute to cytokine imbalance and immune dysregulation in patients with systemic mastocytosis (SM), according to a recently published study in Clinical and Translational Allergy. Although mast cells are the key cells involved in SM pathogenesis, increasing new evidence suggests that mast cells are not the only…

Scintigraphy Scan

Bone Scintigraphy Facilitates Early Diagnosis of SM

Employing Tc-99m hydroxyl diphosphonate (HDP) bone scintigraphy can be useful in diagnosing systemic mastocytosis (SM), according to a case report published in the International Journal of Paediatric Orthopaedics. The researchers observed diffuse skeletal uptake on the bone scan, and a bone biopsy revealed mast cell infiltration. “Diagnosing [SM] remains challenging due to the contradictory results…

booster shot

Patients With CAD Should Be Monitored After COVID-19 Vaccine, Study Says

Researchers show that patients with pre-existing autoimmune hemolytic anemia (AIHA), including cold agglutinin disease (CAD), should be closely monitored after receiving vaccines against the severe acute respiratory syndrome-2 virus (SARS-CoV-2; COVID-19), as published in Hematology, Transfusion and Cell Therapy. The report highlighted the case of a 33-year-old female with previously diagnosed AIHA who had severe…

Study Shows High Polypharmacy in Older Patients With Hemophilia

Polypharmacy, defined as the use of 5 or more medications per day, has a high prevalence among patients with bleeding disorders such as hemophilia and von Willebrand disease (vWD), according to a recently published multicenter prospective observational study. Polypharmacy is a frequent problem for individuals older than 65 years. Due to the success of replacement…

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