Gastroenterologists

New Nanostructured Lipid Carrier System Could Improve GIST Treatment

Researchers developed a new nanostructured lipid carrier system to deliver imatinib to patients with gastrointestinal stromal tumors (GISTs), as published in Nanomaterials. A small amount of imatinib loaded into the new system will be better than imatinib alone, they said. Imatinib is extensively used for the treatment of GIST. However, the drug can cause side…

Targeting MRP1 Has Therapeutic Potential in Imatinib-Resistant GIST

The N6-methyladenosine (m6A) modification of the multidrug resistance-associated protein 1 (MRP1) mRNA promotes drug resistance in gastrointestinal stromal tumors (GISTs), a new study published in Cancer Letters found. This suggests that MRP1 could be a potential therapeutic target for imatinib-resistant GIST. GISTs are abnormal mesenchymal cell growths of the gastrointestinal tract. Patients undergo complete surgical…

Newly Identified ICU Characteristics May Help Reduce Mortality in CAD

Researchers reported the characteristics and outcomes of adult patients with severe autoimmune hemolytic anemia (AIHA) admitted to the intensive care unit (ICU), as presented at the 63rd American Society for Hematology Annual Meeting & Exposition. AIHA is known to carry a poor prognosis and studies have indicated that the overall mortality rate is between 8% to…

Study Suggests COVID-19 Could Exacerbate CAD

Researchers presented the case of an 83-year old woman with secondary cold agglutinin disease (CAD) whose disease worsened due to a COVID-19 infection, as published in Cureus. “Association between COVID-19 and [cold agglutinin syndrome] is a recent and novel finding,” Yash V. Bhagat and the coauthors of the study wrote. “The lack of established evidence-based…

New Cholangiocarcinoma Noncoding RNA Could Become an Intervention Target

Proteasome 20S subunit alpha 3 antisense RNA 1 (PSMA3-AS1) represents a new cancer-promoting long noncoding RNA in cholangiocarcinoma, as published in Aging. This finding suggests that PSMA3-AS1 could be a target for the treatment of the disease. It is already known that long noncoding RNAs including PSMA3-AS1 play a crucial role in the development and…

Postoperative CA19-9 Shows Prognostic Significance in Cholangiocarcinoma

Researchers concluded that the levels of the carbohydrate antigen 19-9 (CA19-9) had a better prognostic performance in patients with intrahepatic cholangiocarcinoma when measured postoperatively, as published in Frontiers in Oncology. “Patients with elevated preoperative CA19-9 that normalizes after curative resection are associated with comparable long-term survival outcomes compared to those with normal preoperative CA19-9, whereas…

China’s NMPA Accepts ALGS New Drug Application for Maralixibat

China’s National Medical Products Administration (NMPA) accepted the New Drug Application (NDA) for CAN108 (maralixibat) for the treatment of cholestatic pruritus in patients with Alagille syndrome (ALGS) aged 1 year and above. “That the NMPA has accepted the NDA, which we anticipate will also receive priority review, for CAN108 for [ALGS], our first candidate in…

Researchers Emphasize Clinical and Immunohematology Testing for CAD

A patient was diagnosed with cold agglutinin syndrome (CAS) after the discovery of cold-antibody autoimmune hemolytic anemia (cAIHA) and splenic marginal zone lymphoma (MZL), as published in Hematology, Transfusion and Cell Therapy. CAS was recently described as a separate but similar entity to cold agglutinin disease (CAD). “In [CAD], patients may have a B-cell clonal…

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