Gastroenterologists

Patients With DMD Show Improved Upper Limb Function on CAP-1002

Capricor Therapeutics reported improvements in skeletal muscle function in nonambulatory patients with Duchenne muscular dystrophy (DMD) who were treated with the experimental drug CAP-1002, according to a press release by the company.  These results were recorded from the HOPE-2 open-label extension study. According to the findings of this study, patients reported statistically significant improvements in…

FDA Places Hold on Phase 2 DMD Trial for SRP-5051

Sarepta’s Duchenne muscular dystrophy (DMD) drug candidate SRP-5051 (vesleteplirsen) was placed on clinical hold by the US Food and Drug Administration (FDA) due to a serious adverse event of hypomagnesemia that developed during the MOMENTUM clinical trial. The FDA is now requesting information from the company about all cases of hypomagnesemia. “Patient safety is always…

Molecular Genetic Testing: An Important Component in Diagnosing ALGS

Researchers identified a previously classified “idiopathic” gene that is responsible for neonatal/infantile cholestasis, including in patients with Alagille syndrome (ALGS), and presented their results at the 54th annual European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) meeting. The study credits advances in molecular genetics, particularly the use of next-generation sequencing in testing candidate genes…

radiotherapy

Radiotherapy Shows Potential in Managing GISTs

The effectiveness and role of radiotherapy for patients with gastrointestinal stromal tumors (GISTs) may need to be reevaluated, according to findings that were recently published in Cancers. GISTs are believed to be resistant to radiotherapy and their use is primarily for palliative care. However, because patients with GISTs are expected to live longer compared with…

surgery

Data Support Intraoperative Revision of Biliary Margins in CCA

Intraoperative revision of margins from frozen sections could increase overall survival (OS) in patients with perihilar cholangiocarcinoma (CCA), according to a study recently published in Annals of Surgical Oncology. “Achieving a margin-negative resection (R0) is challenging given the anatomic location of tumors and remains the most important prognostic indicator of long-term survival,” the authors wrote.…

ultrasound exam

GISTs Mimic Gynecologic Diseases: A Case Series

Gastrointestinal stromal tumors (GISTs) may sometimes manifest as gynecologic diseases in some patients, according to a case series published in Diagnostics. In the series, 20 different patients had masses or symptoms indicative of possible gynecological disease. A pelvic mass and/or abdominal pain was present in 18 patients and the other 2 had either a rectovaginal…

Cannabidiol

Cannabidiol and Cannabigerol Effectively Inhibit CCA Cells

Cannabidiol (CBD) and cannabigerol (CBG) have antitumor activity on cholangiocarcinoma (CCA) in vitro, according to a new study published in Biomolecules. The researchers found that each compound uses a distinct cell death pathway to inhibit CCA. “We found that both CBD and CBG were effective in inhibiting cholangiocarcinoma cells in vitro in a dose-dependent manner,…

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