extrahepatic cholangiocarcinoma

Cancer cells

SOX9-AS1 Drives Tumor Growth in iCCA Study

Dysregulated patterns of long noncoding RNAs (lncRNAs), such as SOX9-AS1, may have both diagnostic and prognostic values in intrahepatic cholangiocarcinoma (iCCA), according to a recently published study in Clinics and Research in Hepatology and Gastroenterology. Currently, surgical resection is the therapy of choice for patients with iCCA; however, due to the vagueness and late appearance of symptoms, as…

Biliary Surgery, SMAD4, and PBRM1 Predict Metastasis Risk in CCA

Mutations in SMAD4 and PBRM1 as well as a history of biliary surgery are all independent protective factors for metastasis in advanced cholangiocarcinoma (CCA), according to a new study published in the Journal of International Medical Research. The researchers also found that TP53 mutations were significantly more frequent in extrahepatic CCA and that mutations in…

clinical research

CCA Survival Rates Higher After Treatment at Academic/Research Facilities

Patients with hilar and extrahepatic cholangiocarcinoma (CCA) had longer median overall survival times when treated at academic/research programs compared to other facilities, according to data presented at the 2022 American Society of Clinical Oncology Annual Meeting. The median overall survival for patients with CCA treated at academic/research programs was roughly 14 months (95% CI, 14.1-14.8…

RNA

Newly Discovered Circular RNA Suppresses Cholangiocarcinoma Tumor

The upregulation of the circular RNA (circ_0059961) increases the expression of secreted frizzled-related protein 2 (SFRP2) by targeting miR-629-5p, a new study published in Pathology – Research and Practice found. This blocks the proliferation, migration, and invasion of cholangiocarcinoma tumor cells. “Our research indicated that circ_0059961 could be attached as a new biomarker for assessing…

microscope

Lapatinib Inhibits Tumor Growth in Cholangiocarcinoma Organoid

Researchers demonstrated that lapatinib not only inhibits the growth of cholangiocarcinoma (CCA) with overexpressed human epidermal growth factor receptor 2 (HER2) but can also bypass the chemoresistance presented after gemcitabine treatment, as published in Frontiers in Oncology. Bai et al conducted a study to determine the effect of lapatinib, an oral tyrosine kinase inhibitor selective…

Necrosis factor

Verteporfin Exhibits Antitumor Effects in Cholangiocarcinoma Cell Lines

Verteporfin showed antitumor effects in intrahepatic and extrahepatic cholangiocarcinoma cell lines, a new study published in Hepatobiliary & Pancreatic Diseases International found. Moreover, when combined with anti-PD-1, it inhibited tumor growth. Blocking immune checkpoints with immunotherapy has shown little benefit in cholangiocarcinoma. However, research has shown that inhibiting YAP1 signaling using verteporfin could inhibit cell…

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