Endocrinologists

Researchers Uncover Novel Pathology of Amphicrine Phenotype in MTC

Researchers discovered the radiological features and mucin (MUC) immunohistochemical expression patterns of a recent case of amphicrine medullary thyroid carcinoma (MTC) and published their results in Endocrine Pathology. Intra- and extracellular MUC production has been variably documented in benign and malignant thyroid tumors. While the expression and contribution of MUC1 have been significantly studied in…

genome

Broader Genomic Screening Detects Risk of MTC

Broader screening for pathogenic or likely pathogenic variants associated with endocrine tumor syndromes allows the detection of people at risk of developing the diseases, according to a new study published in BMC Medicine. Screening also results in the uptake of risk management and facilitates relevant diagnoses. “Further research will be necessary to continue to determine…

clinicaltrial

New Clinical Trial for LCFAOD Assesses Oral Ketones During Exercise

A new clinical trial assessing whether an oral ketone beverage is safe and well-tolerated during moderate-intensity exercise and whether it is able to raise blood ketones to normal levels in patients with long chain fatty acid oxidation disorders (LCFAODs) has just opened. The early phase 1 trial aims to recruit 5 participants with a confirmed…

thyroid cancer cells

Everolimus Plus Pasireotide-LAR Shows Promise for MTC

Everolimus plus long-acting release pasireotide (pasireotide-LAR) has promising efficacy compared to a single agent for the treatment of radioiodine-refractory differentiated thyroid cancer and medullary thyroid carcinoma (MTC), according to the results of a randomized phase 2 clinical trial that was published in Cancers. The aim of the trial was to assess the clinical efficacy and…

MTC

External Beam Radiation Therapy Useful in Treating Thyroid Carcinomas

Researchers have discovered that external beam radiation therapy (EBRT) is a valuable tool in managing patients with thyroid carcinomas, according to a study published in Cancer Reports. The incidence of thyroid carcinomas has risen in recent years. They are histologically categorized into medullary thyroid carcinoma (MTC), differentiated thyroid carcinoma (DTC), and anaplastic thyroid carcinoma (ATC). …

global

Proposed Model Estimates Prevalence of LCFAOD

A modeling methodology for estimating the prevalence of rare diseases has been proposed and demonstrated for long chain fatty acid oxidation disorder (LCFAOD). The proposed model, published in Advances in Therapy, utilizes newborn screening reports and applies them to key modifiers. The modifiers include changes in population growth over time and variable standardization rates of…

abdominal pain

Gastrointestinal Adverse Effects Common With Selpercatinib Treatment for MTC

A new study has found gastrointestinal adverse effects to be more common with selpercatinib for medullary thyroid cancer (MTC) than previously thought. The study, published in the Journal of Clinical Endocrinology & Metabolism, noted that the effects were generally self-limiting but required dose adjustments. “During [the LIBRETTO-001 clinical trial], as an international site, we observed…

thyroid tumor

Comorbid Medullary and Papillary Thyroid Carcinomas: A Rare Case Report

A rare case of co-occurring medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) is described in a study published in the Open Journal of Pathology. MTC and PTC have different tissue origins and clinicopathological manifestations and rarely occur in the same patients, the authors wrote. The 44-year-old female patient had MTC on the left…

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