Diagnosis & Disease Information

MTC surgery

Persistently Elevated Calcitonin in Resected Medullary Thyroid Carcinoma: A Case Report

A patient with multiple endocrine neoplasia type 2B (MEN2B) experienced persistently elevated levels of calcitonin and enlarged cervical lymph nodes despite undergoing radical thyroidectomy with multiple lymph node resections to treat medullary thyroid carcinoma (MTC), according to a recently published case report in JCEM Case Reports. The autosomal dominant hereditary cancer syndrome MEN2B is characterized…

MTC antitumor

Novel Biomarker May Predict Prognosis and Immune Infiltration in MTC

Transmembrane protease serine 4 (TMPRSS4) may be a novel biomarker that can predict prognosis and immune infiltration in thyroid carcinoma, including medullary thyroid carcinoma (MTC), according to a new study published in BMC Endocrine Disorders. TMPRSS4 is already associated with the prognosis of many types of cancer. However, its role in immune infiltration in thyroid…

MTC complications

Microbubble Contrast Agent May Accurately Identify Lymph Node Involvement in MTC

A novel contrast imaging method could effectively assess lymphatic involvement in patients with medullary thyroid carcinoma (MTC) and other thyroid neoplasms, according to a study recently published in Frontiers in Bioengineering and Biotechnology. “Microbubble contrast agent SonoVue is a valuable imaging contrast medium for thorough preoperative lymphatic mapping in patients with thyroid carcinoma, including the…

Clinical Features

MTC Referrals Increase After the Release of Management Guidelines

Surgical referrals of patients with REarranged during Transfection (RET) proto-oncogene mutations, which could lead to medullary thyroid carcinoma (MTC) and multiple endocrine neoplasia type 2 (MEN2), show a trend with publications related to the clinical management of the disease, according to a study published in Endocrine. During the study, a rise in referrals to a…


AI System Can Accurately Diagnose Rare Thyroid Carcinomas Such as MTC

A generally trained artificial intelligence (AI) automatic diagnosis system can differentially diagnose benign and rare malignant thyroid carcinoma nodules, such as those of medullary thyroid carcinoma (MTC), with high accuracy, according to a new study published in Endocrine.  “It may assist radiologists for screening of rare malignancy nodules that even senior radiologists are not acquainted…

examining tissues in a lab

Researchers Name Potential New Prognostic Marker and Immunotherapy Target in MTC

Levels of dipeptidyl peptidase 4 (DPP4) are higher in medullary thyroid carcinoma (MTC) tissues than in paracancerous tissues, a new study published in the International Journal of Endocrinology found. DPP4 levels could potentially be used as a prognostic marker of thyroid carcinomas, and DPP4 may be an effective target for immunotherapy, according to the authors of…

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