dermatologists

Question mark

Test Your Knowledge About the Etiology of HAE

Which of the statements below about the etiology of hereditary angioedema (HAE) are correct? Select one of the options for each question, then submit your answers to see your score and the average score for everyone who has taken the quiz. Read more about the etiology of HAE.

blood plasma

HAE Drug Candidates Receive Intellectual Property Protection in Europe

The European Patent Office has granted Verseon intellectual property protection covering the company’s plasma kallikrein inhibitors (PKIs) that are being developed for the treatment of hereditary angioedema (HAE) and other chronic conditions. “These novel compounds have unique sets of pharmacological properties that could help hundreds of millions of people around the world,” David Kita, Verseon’s…

New Methods Could Improve PAH Screening in Patients With Scleroderma

Ergospirometry and right heart catheterization demonstrated better efficacy for screening for pulmonary arterial hypertension (PAH) in patients with scleroderma than current methods, according to a study recently published in Medicina Clínica. “The incorporation of ergospirometry in the PAH screening algorithm in high risk populations such as those with scleroderma could increase the sensitivity of screening,…

boy scratching skin

Study Finds Maralixibat Improves Quality of Life for Children With Alagille Syndrome

The use of maralixibat in children with Alagille syndrome is associated with better health-related quality of life outcomes, researchers reported in a study published in The Journal of Pediatrics. Studies have demonstrated that children with this disease have much lower health-related quality of life scores than healthy age-matched individuals. One of the more unpleasant symptoms…

pregnant woman

Case Study Suggests Icatibant Is Safe for Pregnant Women With HAE

Researchers from Croatia presented their experience in using icatibant to treat a pregnant patient with hereditary angioedema in a review published in the journal Current Allergy and Asthma Reports.  “Considering the limited number of attacks that our patient usually experiences, which continued at more or less the same frequency during pregnancy, we feel icatibant to…

experimental therapies

Genome-Editing Drug Candidate for HAE Receives Orphan Drug Designation

A new investigational clustered regularly interspaced short palindromic repeats (CRISPR)/Cas 9 gene-editing therapy for the treatment of hereditary angioedema (HAE) has received Orphan Drug designation from the US Food and Drug Administration (FDA).  This is an important milestone for the development of the drug candidate, as it can speed up its approval and entry into…

blood research

Bradykinin Receptor 1 Expression May Play a Role in Hereditary Angioedema

Researchers have discovered that the expression of bradykinin receptor 1 may play an important role in the pathomechanism of hereditary angioedema, according to a study published in the International Journal of Molecular Sciences. Hereditary angioedema is driven by a lack of C1-inhibitor protein, which is caused by mutations in the SERPING1 gene. “C1-inhibitor deficiency causes…

Thrombosis

Patients With HAE Are at an Increased Risk of Thrombotic Events

The association between hereditary angioedema (HAE) and venous thromboembolism (VTE) may be more prominent than initially thought, according to a study recently published in the Journal of Thrombosis and Haemostasis. “In summary, the present study indicates that patients with HAE have a significantly increased risk of composite VTE but not composite [arterial thromboembolism (ATE)],” the…

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