CAD Presents With Digital Gangrene: A Case Report

Cold agglutinin disease (CAD) can present as black fingertips and dark urine, according to a new case report published in QJM: An International Journal of Medicine. The case involved a previously healthy 55-year-old woman who was found to have digital gangrene, elevated cold agglutinin titer, and a monoclonal immunoglobulin M-kappa protein without MYD88 L265P mutation,…

White blood cells

Novel Therapeutic Approach for CAD Targets Complement Activation

Researchers reviewed the current therapies for cold agglutinin disease (CAD) and determined that reducing monoclonal immunoglobulin M (IgM) synthesis constitutes rituximab, bortezomib, and bendamustine, as published in Hematology/Oncology Clinics of North America. In contrast, new approaches focus on impeding complement activation with sutimlimab while reducing the use of cytotoxic agents. The literature review conducted by…

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