autoimmune hemolytic anemia

Vials With the Covid-19 Vaccine and Syringes are Displayed On a Tray at the Corona Vaccination Center

COVID-19 Vaccination Linked With Detection of CAD

Researchers revealed that the global vaccination against COVID-19 has led to the detection of autoimmune hematologic disorders such as cold agglutinin disease (CAD), as published in Vaccines. They noted that while these serious adverse events are rare, they can be life-threatening, and therefore rapid and accurate diagnoses are essential. “Vaccines against SARS-CoV-2, like other ones,…

Sick female lying on bed in ICU

COVID-19 Associated With AIHA: A Case Report

A rare case has been reported of a patient with autoimmune hemolytic anemia (AIHA), thrombocytopenia, and acute kidney injury, as published in Cureus. The researchers noted that the patient ultimately recovered well without the need for corticosteroids. “The underlying pathophysiologic molecular mechanism in virus-induced cell death is not well known; however, it is thought to be…

booster shot

Patients With CAD Should Be Monitored After COVID-19 Vaccine, Study Says

Researchers show that patients with pre-existing autoimmune hemolytic anemia (AIHA), including cold agglutinin disease (CAD), should be closely monitored after receiving vaccines against the severe acute respiratory syndrome-2 virus (SARS-CoV-2; COVID-19), as published in Hematology, Transfusion and Cell Therapy. The report highlighted the case of a 33-year-old female with previously diagnosed AIHA who had severe…

lymphomas

Differential Diagnosis of CAD Should Include Lymphoma, Study Says

Patients diagnosed with cold agglutinin disease (CAD) should always rule out lymphoma as a possible differential or coexistent diagnosis, according to a case report recently published in the International Journal of Laboratory Hematology. The study describes a 64-year-old male with a history of diffuse large B-cell lymphoma (DLBCL) that had compromised testis, treated with chemotherapy…

Thrombosis

Thrombosis Associated With Hemolysis and Multitreatment in CAD

Researchers explored the association between thrombotic events and autoimmune hemolytic anemia (AIHA), a common occurrence in patients with cold agglutinin disease (CAD). They found thromboses in these patients to be associated with intravascular hemolysis, multitreatment, the need for transfusions, and infections, as published in the Journal of Thrombosis and Haemostasis. “Recent epidemiologic studies found a…

PCR test

Case Report: Treating CAD Following COVID-19 Infection

Researchers from Malaysia reported the case of a woman who developed cold agglutinin disease (CAD) following a COVID-19 infection. “We believe that her condition deteriorated due to the ‘cytokine storm’ and complement cascade,” they wrote in an article published in the Hong Kong Medical Journal. The link between autoimmune hemolytic anemia such as CAD and…

genetic testing

Researchers Identify New Therapeutic Targets for CAD

An appropriate molecular diagnosis of inborn errors of immunity, including cold agglutinin disease (CAD), directly impacts the prognosis while also allowing the use of novel target therapies, according to a new study published in Frontiers in Immunology. These potential therapies can correct abnormal functioning of the typical immune responses in these diseases. The team of…

cell immunotherapy

Cases of CAD Secondary to Immunotherapy Increasing, Study Finds

The number of cases of cold agglutinin disease (CAD) and other hematological diseases associated with the use of immunotherapeutic agents is escalating, according to a new study published in Hematology/Oncology Clinics of North America. Hwang et al reported that the rise of immune-related CAD and other hematologic adverse events might relate to the increasing use…

Reactivity Testing Differentiates CAD From Other AIHA Types

The use of reactivity testing and genotyping is necessary to differentiate cold agglutinin disease (CAD) from other forms of autoimmune hemolytic anemia (AIHA) to provide optimal care for patients, according to a new study published in Hematology/Oncology Clinics of North America. “In the presence of autoantibodies, the failure to identify an underlying alloantibody may lead…

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