Researchers reported success in employing cardiac magnetic resonance tissue tracking (CMR-TT) to evaluate left ventricular (LV) and right ventricular (RV) strain parameters in patients with pulmonary arterial hypertension (PAH), as published in the Journal of Clinical Medicine. They also found the technique to be effective in detecting early biventricular myocardial damage.

“RV function failure is the main cause of death in PAH patients, and there is increasing evidence of the importance of right ventricular systolic parameters,” the authors wrote.

“It has been reported that RV function is one of the major prognostic predictors of PAH, and the purpose of this study was to retrospectively analyze the correlation between the LV and RV strain, as well as the ventricular strain changes associated with cardiac function preservation among PAH patients.”

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The research team retrospectively analyzed data from 47 patients with PAH who had undergone cardiac magnetic resonance imaging between 2017 and 2020. They assessed biventricular myocardial strain parameters using quantitative tissue techniques without contrast, also known as CMR-TT.

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The global radial strain, global circumferential strain, and global longitudinal strain (GLS) of the left and right ventricles correlated well in a Bland-Altman analysis, demonstrating the feasibility and reproducibility of this technique to evaluate these parameters.

The researchers found that only the GLS differed significantly between patients with preserved LV function and healthy controls. The analysis also demonstrated that patients with PAH typically had impaired LV function and that LV GLS may be associated with a poor prognosis.

They also noted that in addition to its feasibility and repeatability in assessing early LV and RV strain parameters, the CMR-TT technique is nonradioactive and noninvasive, further increasing its usefulness in this patient group.


Cao J, Li S, Cui L, Zhu K, Huo H, Liu T. Biventricular myocardial strain analysis in patients with pulmonary arterial hypertension using cardiac magnetic resonance tissue-tracking technology. J Clin Med. 2022;11(8):2230. doi:10.3390/jcm11082230