PAH News Briefs

cardiopulmonary system

Pulmonary Artery Denervation Safe and Effective in PAH, Trial Results Suggest

Pulmonary artery denervation improves exercise capacity, hemodynamics, and clinical outcomes in patients with World Health Organization (WHO) Group 1 pulmonary arterial hypertension (PAH), according to results from a clinical trial testing the safety and efficacy of the procedure, called PADN-CFDA. “The PADN-CFDA results are very important because this was an adequately powered randomized controlled trial…

macrophage cell

Bruton’s Tyrosine Kinase Could Be a Potential Therapeutic Target for PAH

Researchers from China showed that inhibition of Bruton’s tyrosine kinase (BTK) improved pulmonary arterial hypertension (PAH), pulmonary vascular remodeling, and right ventricle hypertrophy in a rodent model of PAH. Moreover, it alleviated pulmonary vascular fibrosis and decreased endothelial-to-mesenchymal transition (EndMT). “These beneficial effects of BTK inhibition are associated with the suppression of [nucleotide-binding oligomerization domain-like…

genes

Bioinformatics Analysis Reveals New Potential Therapeutic Targets in PAH

A new bioinformatics study offers insight into the pathogenesis of pulmonary arterial hypertension (PAH) as well as 10 newly identified hub genes that could represent potential treatment targets for the disease. The study, published in the Canadian Respiratory Journal, employed multiple microarray analyses to provide a theoretical basis for future research in PAH. “Although basic…

human lungs

Lung Transplant Allocation Among Patients With PAH Remains Inequitable

Researchers reported that patients with pulmonary arterial hypertension (PAH) remain least likely to receive a lung transplant and hence most likely to die while on the waiting list, despite recommendations made in 2015. The findings were published in the American Journal of Respiratory and Critical Care Medicine. PAH, characterized by elevated pulmonary vascular resistance, is potentially…

New Methods Could Improve PAH Screening in Patients With Scleroderma

Ergospirometry and right heart catheterization demonstrated better efficacy for screening for pulmonary arterial hypertension (PAH) in patients with scleroderma than current methods, according to a study recently published in Medicina Clínica. “The incorporation of ergospirometry in the PAH screening algorithm in high risk populations such as those with scleroderma could increase the sensitivity of screening,…

Cardiovascular system

Systemic Sclerosis-Associated PAH Carries a Poorer Prognosis Than Idiopathic PAH

Researchers have discovered that patients with pulmonary arterial hypertension (PAH) associated with systemic sclerosis have considerably poorer outcomes than patients with idiopathic PAH, according to a study published in Chest. PAH is driven by high pulmonary arterial pressures and extensive pulmonary vascular resistance. Two of the most common subtypes are idiopathic PAH and PAH associated…

pulmonary artery

Reduced mPAP Improves Clinical Outcomes in Patients With PAH

Researchers have discovered that a decreased mean pulmonary arterial pressure (mPAP) of 35 mmHg or less can significantly improve clinical outcomes in patients with pulmonary arterial hypertension (PAH) of various etiologies, according to a study published in Vascular Pharmacology. PAH is characterized by a rise in precapillary pressure, resulting in remodeling of the pulmonary vasculature.…

data

Sex, Age, and Body Mass Index Associated With Outcomes in PAH

A new study has revealed sexual dimorphism in regard to 6-minute walk distance (6MWD), hemodynamics, and body mass index (BMI) in patients with pulmonary arterial hypertension (PAH). The study, published in the Annals of the American Thoracic Society, noted that female patients had shorter 6MWDs and less hemodynamic impairment than male patients and that these…

DNA strand

Cell-Free DNA Levels Could Be a Prognostic Biomarker of Survival in PAH

Levels of circulating cell-free DNA are higher in patients with pulmonary arterial hypertension (PAH), a new study published in Circulation found. These levels also correlate with the severity of disease and can predict survival. The significance of cell-free DNA, a marker of cellular injury, was not yet known in PAH.  Here, a team of researchers…

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