A new clinical trial that aims to determine the frequency and severity of restless legs syndrome in people with neuromyelitis optica spectrum disorder (NMOSD) is now recruiting participants in Turkey.

The investigators set out to compare the sleep quality, level of daytime sleepiness, quality of life, fatigue, and magnetic resonance imaging results in NMOSD patients. Finally, the study will compare the cognitive functions of NMOSD patients, who have restless legs syndrome and those who do not.

The trial, sponsored by Dokuz Eylul University in Izmir, Turkey, aims to recruit 30 patients, who are 18 years of age and above. During the observational trial, patients will not receive any interventions. 


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Patients who are diagnosed with severe cognitive and/or psychiatric impairment and those who have another condition known to be associated with restless legs syndrome are not eligible to take part in the trial.

The primary outcome measure of the study is the severity of the symptoms of restless legs syndrome, which will be assessed using the International Restless Legs Syndrome Study Group rating scale.

Secondary outcome measures include sleep disturbances or deficits, daytime sleepiness as measured by the Epworth Sleepiness Scale, fatigue as assessed using the Modified Fatigue Impact Scale as well as information processing speed, verbal memory, and visuospatial memory.

Other outcome measures include neurological disability as assessed by the Expanded Disability Status Scale.

The trial started on October 1, 2022, and is expected to be completed on September 1, 2023. 

Restless legs syndrome is a neurological condition of unknown etiology in which patients experience an urge to move their legs, especially while at rest. The condition can be associated with various others, including anemia, uremia, neuropathies, rheumatoid arthritis, Parkinson’s disease, spinocerebellar ataxia, and multiple sclerosis.

The relationship between restless legs syndrome and NMOSD remains poorly understood. 

Reference

Restless legs syndrome in people with neuromyelitis optica spectrum disorder. US National Library of Medicine. Updated October 10, 2022. Accessed October 13, 2022.