NMOSD News Briefs

plasma

Elevated Plasma C5a Levels Correlate With Pain in NMOSD

Researchers found elevated plasma levels of complement 5 (C5)-a and other inflammatory cytokines in patients with neuromyelitis optica spectrum disorder (NMOSD) during remission, as published in Neuropsychiatric Disease and Treatment. This is the first study to demonstrate the relationship between C5a levels in peripheral blood and pain in patients with NMOSD during remission, the authors…

anxiety and depression

Patients Report Psychological and Physical Impact of Living With NMOSD

Symptom severity, pain, fatigue, depression, and work-related barriers caused by neuromyelitis optica spectrum disorder (NMOSD) strongly affect the quality of life in patients with the disease, according to a new study published in Neurology and Therapy. Researchers conducted an observational, multicenter, cross-sectional study in Spain from November 2019 to July 2020 to assess the impact…

MRI head scan

Lesion Location and Morphology Aid in NMOSD Diagnosis

Certain symptoms and abnormal findings in imaging studies may be useful to differentiate the first attack of neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS), according to a study recently published in Frontiers in Neurology. The authors registered demographic, clinical manifestations, Expanded Disability Status Scale (EDSS) scores, and head magnetic resonance imaging (MRI) findings…

scientist researching

Ravulizumab-cwvz Meets Primary Endpoint in Phase 3 NMOSD Trial

Ravulizumab-cwvz (Ultomiris®) reduces the risk of relapse in adults with anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (NMOSD), according to results from an open-label phase 3 clinical trial called CHAMPION-NMOSD. “These trial results show that Ultomiris may help patients move towards eliminating relapses, which is an important advancement in the treatment of NMOSD,” said Marc Dunoyer…

brain MRI

Demyelinated Brain Lesion Locations on MRI Can Help Differentiate MS and NMOSD

Clinicians and neuroradiologists can differentiate multiple sclerosis (MS) from neuromyelitis optica spectrum disorder (NMOSD) and MOG antibody-associated disorder (MOGAD) by the location of demyelinated lesions on brain magnetic resonance imaging (MRI), according to findings published in the Journal of Clinical Neuroscience. Researchers at the New York University Grossman School of Medicine in New York City…

dna sequencing

Case Studies Suggest Etiopathogenetic Link Between NMOSD and Myasthenia Gravis

Two cases of coexisting neuromyelitis optica spectrum disorder (NMOSD) and myasthenia gravis (MG) suggest a possible etiopathogenetic link between the diseases, reports a study published in Multiple Sclerosis and Related Disorders. Using next-generation sequencing (NGS), 2 mutant human leukocyte antigen (HLA) alleles were found in common between the 2 patients—HLA-DQA1*05:01:01 and HLA-DPB1*04:02:01. “To summarize, although…

MRI cervical

Researchers Identify Prognostic Features in Early- vs Late-Onset NMOSD

Patients with late-onset neuromyelitis optica spectrum disorder (NMOSD) exhibited more severe disabilities than patients with early-onset NMOSD, according to new findings published in Frontiers in Neurology. Researchers conducted a retrospective study of 71 patients diagnosed for at least 3 years with NMOSD in central China between January 2012 and January 2021. In 39 patients, late-onset…

MRI scan of normal brain

MRI T2-Relaxation Time Useful in Monitoring NMOSD Activity

Patients with neuromyelitis optica spectrum disorder (NMOSD) have increased magnetic resonance imaging (MRI) T2-relaxation times (T2rt) compared to healthy controls, according to a new study published in the Journal of Neurology, Neurosurgery & Psychiatry. Those patients with active NMOSD had even further increased T2rt compared to those who were clinically stable. Increased T2rt was observed…

Varicella zoster viruses

Study Suggests Possible Causal Relationship Between Varicella Zoster Virus and NMOSD

A study recently published in the Journal of NeuroVirology found that viral infections often precede neuromyelitis optica spectrum disorders (NMOSD), and varicella zoster virus (VZV) could be the most common agent involved. The study describes a plausible causal relationship between VZV infection and NMOSD that may represent an unusual clinical scenario posing several diagnostic and…

coronavirus vaccine

New Humoral Response Data Show COVID-19 Vaccine Is Useful in NMOSD

The humoral response becomes impaired after COVID-19 vaccination in patients with neuromyelitis optica spectrum disorder (NMOSD) treated with B-cell depleting therapies, a new study published in Multiple Sclerosis and Related Disorders found. However, seroconversion occurred in almost all patients treated with conventional synthetic disease-modifying immunosuppressants after COVID-19 infection or vaccination. The authors of the study…

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