Idiopathic pulmonary fibrosis

A group of researchers from China has developed a new imaging tool, called Cy-COX, to monitor levels of cyclooxygenase-2 (COX-2) in idiopathic pulmonary fibrosis (IPF).

According to Wang et al, “Cy-COX is a fast and convenient imaging tool with great potential to predict the early stage of pulmonary fibrosis and evaluate the therapeutic effects.”

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Cy-COX presented a significant enhancement of the fluorescence signal, with selectivity and sensitivity to COX-2. By using the near-infrared fluorescent probe, Cy-COX, the study demonstrated levels of COX-2 increased in the early stage of IPF and decreased in the late stage with disease progression.

Moreover, they concluded COX-2 overexpression did attenuate the severity of pulmonary fibrosis.

COX-2 has been associated to IPF pathogenesis, with several studies suggesting COX-2 dysregulation contributes to pulmonary fibrosis.

Reference

Wang Y, Wei Y, He N, et al. Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models. J Mater Chem B. Published online July 10, 2021. doi:10.1039/D1TB01307F