An upcoming study will evaluate the characteristics and patterns related to the surgical treatment of medullary thyroid cancer (MTC) and other thyroid neoplasms.

Researchers have already initiated the recruiting process for this observational study. This cohort retrospective research will include almost 4000 participants from different European centers previously diagnosed with any subtype of thyroid cancer included in the EUROCRINE® database.

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The authors will identify and report the characteristics of each case to analyze the clinical data of patients with a thyroid neoplasm, and a special emphasis on the surgical procedure and its findings, such as operation extent and the performance or not of lymphadenectomy and/or multivisceral resection—likewise, postoperative findings including overall morbidity and progression of each patient after surgical resection of the tumor.

The researchers aim to compare these results to current guidelines on the management of thyroid cancer, with a focus on the advanced disease of each cancer subtype, especially since most recommendations for this population are rather scarce due to the lack of supporting evidence.

The authors aim to record the perioperative characteristics in a descriptive analysis of all participants prior to, during, and after surgery as the primary outcome.

Moreover, the study will report any short-term clinical outcomes such as complications related to the surgery, including bleeding, lymphorrhea, recurrent laryngeal nerve paralysis and its complications, tracheal or esophageal injury, hypocalcemia, and hypoparathormonemia. The overall survival, recurrence, and mortality will constitute another reported outcome.

Individuals of 18 years of age or older, of both sexes, with a confirmed diagnosis of either MTC, papillary thyroid carcinoma, follicular thyroid carcinoma, or anaplastic thyroid carcinoma, who had undergone surgical resection of the tumor, can become part of the sample.

This novel research, titled “European Multicenter Study on Surgical Management of Advanced Thyroid Cancer (ATCEU),” started on December 15, 2022, and is expected to be completed by September 2023.


European multicenter study on surgical management of advanced thyroid cancer (ATCEU). Accessed April 5, 2023.