A web-based survey concluded that thyroid cancer survivors experienced increased anxiety during the COVID-19 pandemic when compared to the prepandemic era, as published in Endocrine Practice. Most (83%) respondents indicated that their lives were very different during the pandemic. The study enrolled 378 responders who met all inclusion criteria. These included patients diagnosed with thyroid…
Analogs of the heath shock protein 70 (HSP70) inhibitor MKT-077 can suppress human medullary thyroid carcinoma (MTC) cells in culture and mouse xenografts, according to results of a new study published in the International Journal of Molecular Sciences. MKT-077 is a water-soluble rhodocyanine dye analog. Previous studies have shown that it can inhibit mortalin, a…
Patients with medullary thyroid cancer (MTC) who are treated with selpercatinib and have an objective tumor response can have a lasting increase in serum carcinoembryonic antigen (CEA) levels, according to a new case study published in European Thyroid Journal. “The mechanism behind this unexpected rise in CEA level remains unknown,” the researchers wrote. Normally, levels of…
A rare case of large a medullary thyroid cancer (MTC) tumor with extremely elevated calcitonin levels but no signs of metastization was recently reported in the journal Cureus. “This case report highlights the value of genetic studies on disease prognostication and the need for comprehensive research studies on genomic profiling in MTC to better understand…
Researchers showed the most common form of collision tumors in the thyroid included medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC), as published in Archive of Clinical Cases. PTC can often be found in the background thyroid of patients receiving surgery for MTC, and incidental findings from autopsies report as high as 35% of…
Pediatric thyroid carcinomas that are diagnosed and treated early carried a better prognosis, according to a study published in the International Journal of Pediatric Otorhinolaryngology. Tawde and Jeyakumar made the discovery after reviewing trends in pediatric thyroid carcinomas, including medullary thyroid carcinoma (MTC), using data from the Surveillance, Epidemiology, and End Results (SEER) database. Thyroid…
A new study showed promising results for the use of the β-amyloid-specific radiotracer [18F]AV-45 in medullary thyroid carcinoma (MTC) diagnosis with positron emission tomography (PET)/computed tomography (CT) imaging. “In this first-in-human pilot clinical study, we have demonstrated that [18F]AV-45 exhibits selective and specific uptake by the amyloid plaques in MTC tissue samples,” the study authors…
A team from Kuma Hospital in Kobe, Japan reported the case of a patient with a melanin‑producing medullary thyroid carcinoma (MTC) that evolved into melanoma. The case, published in Molecular and Clinical Oncology, was the second of its kind to be reported. “In comparison with the case reported previously, the morphology of the present case…
The diagnostic accuracy of calcitonin levels in fine-needle aspirate (Ct-FNA) washout fluid is greater than that of cytology in medullary thyroid carcinoma (MTC), a new study published in the Turkish Journal Of Medical Sciences found. They would, therefore, be complementary to cytology results. The researchers also demonstrated that the ratio of Ct-FNA over serum calcitonin…
Researchers reviewed the literature for studies exploring the pharmacological profile of withaferin A focusing on its anticancer potential, as published in the journal Molecules. They found that there are many in vitro and in vivo studies about withaferin A’s wide range of pharmacological profiles including anticancer, anti-inflammatory, antiherpetic, antifibrotic, immunosuppressive, and antileishmanial abilities. Many studies…
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