MTC News Briefs

MTC Survivors May Be Disproportionately Affected by COVID-19

A web-based survey concluded that thyroid cancer survivors experienced increased anxiety during the COVID-19 pandemic when compared to the prepandemic era, as published in Endocrine Practice. Most (83%) respondents indicated that their lives were very different during the pandemic. The study enrolled 378 responders who met all inclusion criteria. These included patients diagnosed with thyroid…

Mortalin Inhibition May Have Therapeutic Potential in MTC

Analogs of the heath shock protein 70 (HSP70) inhibitor MKT-077 can suppress human medullary thyroid carcinoma (MTC) cells in culture and mouse xenografts, according to results of a new study published in the International Journal of Molecular Sciences. MKT-077 is a water-soluble rhodocyanine dye analog. Previous studies have shown that it can inhibit mortalin, a…

CEA Levels May Increase in MTC After Successful Selpercatinib Treatment

Patients with medullary thyroid cancer (MTC) who are treated with selpercatinib and have an objective tumor response can have a lasting increase in serum carcinoembryonic antigen (CEA) levels, according to a new case study published in European Thyroid Journal. “The mechanism behind this unexpected rise in CEA level remains unknown,” the researchers wrote. Normally, levels of…

Researchers Associate Large Benign MTC Tumor With Certain Mutation

A rare case of large a medullary thyroid cancer (MTC) tumor with extremely elevated calcitonin levels but no signs of metastization was recently reported in the journal Cureus. “This case report highlights the value of genetic studies on disease prognostication and the need for comprehensive research studies on genomic profiling in MTC to better understand…

child thyroid check

Early Detection, Treatment Key to Better Prognosis in Pediatric Thyroid Cancer

Pediatric thyroid carcinomas that are diagnosed and treated early carried a better prognosis, according to a study published in the International Journal of Pediatric Otorhinolaryngology. Tawde and Jeyakumar made the discovery after reviewing trends in pediatric thyroid carcinomas, including medullary thyroid carcinoma (MTC), using data from the Surveillance, Epidemiology, and End Results (SEER) database. Thyroid…

A PET Tracer May Improve Diagnosis of Medullary Thyroid Carcinoma

A new study showed promising results for the use of the β-amyloid-specific radiotracer [18F]AV-45 in medullary thyroid carcinoma (MTC) diagnosis with positron emission tomography (PET)/computed tomography (CT) imaging. “In this first-in-human pilot clinical study, we have demonstrated that [18F]AV-45 exhibits selective and specific uptake by the amyloid plaques in MTC tissue samples,” the study authors…

Preoperative Technique Can Predict Metastasis in Recurrent MTC

The diagnostic accuracy of calcitonin levels in fine-needle aspirate (Ct-FNA) washout fluid is greater than that of cytology in medullary thyroid carcinoma (MTC), a new study published in the Turkish Journal Of Medical Sciences found. They would, therefore, be complementary to cytology results. The researchers also demonstrated that the ratio of Ct-FNA over serum calcitonin…

Plant Compound Recommended for MTC Clinical Trials

Researchers reviewed the literature for studies exploring the pharmacological profile of withaferin A focusing on its anticancer potential, as published in the journal Molecules. They found that there are many in vitro and in vivo studies about withaferin A’s wide range of pharmacological profiles including anticancer, anti-inflammatory, antiherpetic, antifibrotic, immunosuppressive, and antileishmanial abilities. Many studies…

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