MTC News Briefs

Medullary Thyroid Cancer Diagnosis

Radiolabeled Somatostatin Analogs May Be Useful in Managing Recurrent MTC

Radiolabeled somatostatin analogs can be useful for the management of recurrent medullary thyroid carcinoma (MTC) after a thyroidectomy, according to a study. The results showed that gallium-68 dodecane tetraacetic acid tyr3-octreotate positron emission tomography-computed tomography (68Ga-DOTATAE PET-CT) had a relatively high detection rate, and peptide receptor radionuclide therapy with 177Lu-DOTATATE was a safe alternative for…

CT scan

New Study to Investigate 18F-PSMA Positron Emission Tomography for MTC

A new observational study aims to assess the feasibility of using F-18 labeled prostate-specific membrane antigen (18F-PSMA) as a tracer for positron emission tomography/computer tomography (PET/CT) imaging for the staging of medullary thyroid carcinoma (MTC). The study will also compare 18F-PSMA to the most commonly used tracer in clinical practice, F-18 labeled fluorodeoxyglucose (18F-FDG), to…

MTC Overview

New Tyrosine Kinase Inhibitors May Provide Therapeutic Benefit for MTC

Sulfatinib and SPP86 show antitumor activity both in medullary thyroid carcinoma (MTC) cell lines and a zebrafish model of thyroid cancer, a recent study suggests. Sulfatinib is a multitarget kinase inhibitor selective for fibroblast growth factor receptor-1 (FGFR-1) and the vascular endothelial growth factor receptor (VEGFR) 1, 2, and 3, while SPP86 is a RET-specific…

Ultrasound detail

Ultrasonographic Features May Aid in Diagnosing Cervical Lymph Node Metastases From MTC

Cervical lymph node metastases from medullary thyroid cancer (LNM-MTC) seemed to have sonographic features of fewer calcifications, lack of hilum, and larger size in comparison to the lymph node metastases from papillary thyroid cancer (LNM-PTC), a study suggests. The results showed similarities in long-axis diameter, short-axis diameters, gender, shape, cystic change, echogenicity, border, vascularity, and…

human lymph node

Alternatives to TNM May Be Superior for Predicting Survival in MTC

Metastatic lymph node ratio (MLNR) could become the method of choice to predict cancer-specific survival in patients with medullary thyroid carcinoma (MTC), according to an article recently published in Head & Neck. “Metastatic lymph node ratio stratifies cancer-specific survival in patients with MTC better than the number of node metastases or [Tumor Node Metastasis/American Joint…

MTC prognosis

MTC Tumor Grade Predicts Calcitonin Doubling Time and Recurrence

A new study has demonstrated that patients with high-grade medullary thyroid carcinoma (MTC) often have a calcitonin doubling time of less than 2 years, which is associated with poorer outcomes and tumor recurrence. The study, published in Thyroid, found significantly slower calcitonin doubling times among patients with low-grade tumors. “In this study, our object was…

surgery

Novel Tension-Free Thyroidectomy Technique Improves Surgical Outcomes

Researchers reported their novel technique of tension-free thyroidectomy is a safe method of surgery with notably positive surgical outcomes. Their study was published in Updates in Surgery. Thyroidectomy is indicated in patients with medullary thyroid carcinoma, papillary carcinoma, multinodular toxic goiter, and follicular neoplasia. It is a risky procedure that can lead to a number…

NORD banners

Rare Disease Patients and Advocate to Headline NORD Conference in October

Two rare disease patients and a rare disease advocate will be the keynote speakers at the National Organization for Rare Disorders (NORD) 2022 annual rare disease conference, being held at the Marriott Marquis in Washington, DC, on October 17 and 18, 2022.   NORD announced the keynote speakers as Brittany Clayborne, MS, PsyD, a post-transplant…

human lymph node

New Nomogram Predicts Lateral Lymph Node Metastasis in Patients With MTC

Researchers have developed a new nomogram that can predict lateral lymph node metastasis (LNM) in patients with medullary thyroid cancer (MTC), according to a recent article in Frontiers in Endocrinology. The nomogram was constructed based on data showing that male sex, higher preoperative calcitonin levels, lateral lymph node involvement, and multifocal lesions are all risk…

Next post in MTC News Briefs