Measuring calcitonin levels in the washout fluid of fine-needle aspiration (FNA-CT) is significantly more sensitive than cytology after FNA in detecting medullary thyroid carcinoma (MTC), according to a new study published in Endocrine. “Accordingly, FNA-CT represents the standard method to use in patients with suspicious MTC lesions, combined with cytology,” first author Pierpaolo Trimboli,…
Phase 1 ARROW clinical trial results showed that Chinese trial participants with advanced or metastatic RET-mutant medullary thyroid cancer (MTC) demonstrated an objective response rate of 73.1% to treatment with pralsetinib (Gavreto®), according to CStone Pharmaceuticals. Pralsetinib had a 9-month duration of response rate of 100%, and the drug was tolerated well among these individuals.…
The leading causes of death in medullary thyroid carcinoma (MTC) are complications related to airway obstruction due to tracheal invasion, the progression of distant metastasis, and complications from chemotherapy. Clinical characteristics of the disease are not different according to the timing of distant metastasis. These are the findings of a study published in Cancers that…
A team of German researchers, noting the lack of research on the discontinuation of tyrosine kinase inhibitors (TKIs) after long-term therapy in patients with medullary thyroid carcinoma (MTC), discovered that the discontinuation of vandetanib in patients with stable disease did not automatically cause rapid disease progression. Instead, a period of prolonged “TKI-free” stable disease was…
Investigators presented a rare case study describing the coexistence of medullary thyroid carcinoma (MTC) and malignant skin melanoma within a single patient’s thyroid following a total thyroidectomy, according to Clinical Case Reports. The tumors were separated within the thyroid with no shared anatomy. Upon microscopic evaluation, one tumor was a multinodular goiter, while the other…
Choroidal metastasis as the initial presentation of medullary thyroid carcinoma (MTC) is very rare and challenging to diagnose, a case report and literature review published in the International Journal of Surgery Case Reports concluded. “Surgeons need a high index of suspicion when ocular symptoms accompany a neck mass or thyroid-related symptoms,” the researchers wrote. They…
A survey conducted by a group of European researchers found that most respondents from European countries regularly used gene sequencing in rare thyroid cancers such as medullary thyroid carcinoma, according to a poster presented at the European Society for Medical Oncology (ESMO) Congress 2021. This is despite the fact that selective targeted therapies may not…
Treatment patterns appear to be similar for medullary thyroid carcinoma (MTC) patients with and without REarranged during Transfection (RET) mutations, according to a poster presented at the European Society for Medical Oncology (ESMO) Congress 2021. “Surgery and adjuvant [treatment] patterns were similar between [patients] with RET+ and RET– MTC, indicating a need for broader education…
RET gene testing should be broadened among patients with medullary thyroid carcinoma (MTC) at diagnosis, during localized disease status, and before the initiation of treatment. This was the conclusion of a study presented at the European Society for Medical Oncology (ESMO) Congress 2021, which is taking place online September 16 to 21, 2021. The testing…
German researchers who sought to determine the metastatic risk profile in medullary thyroid cancer (MTC) concluded that “lymphatic invasion predicts lymph node metastases better in medullary thyroid cancer than venous invasion heralds distant metastases.” To evaluate the “suitability of microscopic lymphatic and venous invasion at thyroidectomy” to predict lymph node and distant metastases in MTC,…
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