The lymph node ratio is an independent prognostic factor for disease-free and overall survival in medullary thyroid carcinoma (MTC), according to a new study published in Peer J. Moreover, it also impacted the biochemical cure of the disease. To assess the possible link between lymph node status (i.e. the number of lymph nodes that are…
A case report of a mother and her children with familial medullary thyroid carcinoma (MTC) was presented as an ePoster at the 2023 International Meeting of Pediatric Endocrinology (IMPE 2023). A 32-year-old mother was diagnosed with metastatic MTC after progressive weakness of her extremities, weight loss, and dysarthria. She was found to have a TGC-TGG…
A study submitted to Research Square has revealed that even though uveal metastases (UM) originating from thyroid neoplasms are relatively rare, they might still threaten the eyesight of every patient with thyroid cancer. The study suggested that physicians should be alert and consider the possibility of UM if patients report ocular symptoms, a neck mass, or…
Medullary thyroid carcinoma (MTC) could coexist with ectopic bone formation (EBF) inside the thyroid gland, according to a study recently published in the journal European Review for Medical and Pharmacological Sciences. “Based on our view, we recommend that all patients with histopathological findings of EBF or EMH in thyroid biopsy or thyroidectomy specimens should be…
A recently published study in Pathology – Research and Practice has revealed that in the presence of Val804Met RET, several types of thyroid premalignancy and malignancy should be screened in addition to medullary thyroid carcinoma (MTC). The study suggested that the possibility of multiple tumors should be considered in the setting of RET gene mutation. Additionally, clinical…
A novel imaging method may predict cancer recurrence in patients with a history of medullary thyroid cancer (MTC), according to a study recently published in Molecular Imaging and Radionuclide Therapy. “Although no comparison with 18F-FDG or 68Ga-DOTATATE could be possible in our study, in the follow-up liver lesions showed progression on both CT and MRI,…
Several immunologic markers may predict the presence of aggressive medullary thyroid carcinoma (MTC), according to a study recently published in Endocrinología, Diabetes y Nutrición. “Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) are prognostic factors in several tumors, though little is known in medullary thyroid cancer (MTC),” the authors wrote. Read more about…
Tyrosine kinase inhibitors including vandetanib, pralsetinib, cabozantinib, and selpercatinib significantly improve progression-free survival in patients with medullary thyroid carcinoma (MTC) that has progressed, according to a review article published in the International Journal of Molecular Sciences. A frequent and often serious adverse event associated with their use is hypertension, the researchers noted. This is rarely…
The overall survival of patients with mixed medullary-follicular thyroid carcinoma is significantly worse than that of patients with differentiated thyroid carcinoma, according to a new study published in The American Journal of Surgery. “Our study adds to the growing body of literature characterizing the prognosis and clinicopathologic characteristics of mixed histology thyroid tumors,” the authors…
It is possible to analyze different genetic changes in medullary thyroid carcinoma (MTC) with liquid biopsy, according to a new study published in Pathobiology. These changes may have predictive implications and could potentially be used as prognostic factors. In the present study, a team of researchers from Spain led by David Parada, MD, PhD, from…
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