MTC News Briefs

genome

Broader Genomic Screening Detects Risk of MTC

Broader screening for pathogenic or likely pathogenic variants associated with endocrine tumor syndromes allows the detection of people at risk of developing the diseases, according to a new study published in BMC Medicine. Screening also results in the uptake of risk management and facilitates relevant diagnoses. “Further research will be necessary to continue to determine…

thyroid cancer cells

Everolimus Plus Pasireotide-LAR Shows Promise for MTC

Everolimus plus long-acting release pasireotide (pasireotide-LAR) has promising efficacy compared to a single agent for the treatment of radioiodine-refractory differentiated thyroid cancer and medullary thyroid carcinoma (MTC), according to the results of a randomized phase 2 clinical trial that was published in Cancers. The aim of the trial was to assess the clinical efficacy and…

MTC

External Beam Radiation Therapy Useful in Treating Thyroid Carcinomas

Researchers have discovered that external beam radiation therapy (EBRT) is a valuable tool in managing patients with thyroid carcinomas, according to a study published in Cancer Reports. The incidence of thyroid carcinomas has risen in recent years. They are histologically categorized into medullary thyroid carcinoma (MTC), differentiated thyroid carcinoma (DTC), and anaplastic thyroid carcinoma (ATC). …

abdominal pain

Gastrointestinal Adverse Effects Common With Selpercatinib Treatment for MTC

A new study has found gastrointestinal adverse effects to be more common with selpercatinib for medullary thyroid cancer (MTC) than previously thought. The study, published in the Journal of Clinical Endocrinology & Metabolism, noted that the effects were generally self-limiting but required dose adjustments. “During [the LIBRETTO-001 clinical trial], as an international site, we observed…

thyroid tumor

Comorbid Medullary and Papillary Thyroid Carcinomas: A Rare Case Report

A rare case of co-occurring medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) is described in a study published in the Open Journal of Pathology. MTC and PTC have different tissue origins and clinicopathological manifestations and rarely occur in the same patients, the authors wrote. The 44-year-old female patient had MTC on the left…

ultrasound

ACR Score Best for Differentiating Malignant and Benign Thyroid Nodules, Study Finds

The American College of Radiology (ACR) score is best for differentiating between malignant thyroid nodules and benign nodules and between medullary thyroid carcinoma and papillary thyroid carcinoma, according to a new study. It is followed ex aequo by the ACR Thyroid Imaging Report and Data System (TI-RADS) and the Kwak TI-RADS, the researchers found. The…

therapy

Patients With MTC and MEN2 Report Inattention and Mood Concerns

Researchers reported that patients with multiple endocrine neoplasia type 2 (MEN2) and medullary thyroid carcinoma (MTC) experience psychosocial burdens such as pain affecting their daily life, as well as difficulties in concentrating, as published in Children. MEN2A and MEN2B are often associated with MTC, which is a chronic and indolent disease that can progress without…

insulin molecule

Newly Identified Metabolites Aid in Early Detection of MTC

Three metabolites could help differentiate patients with medullary thyroid carcinoma (MTC) from healthy individuals, according to a new study published in Scientific Reports. These are linoleic acid, linolenic acid, and leucine, and they can potentially be used as tumor biomarkers for the early detection of MTC. The metabolites were identified through the metabolomics profiling of…

thyroid cancer

MTC With Cushing’s Syndrome Successfully Treated With Selpercatinib

A new case report demonstrates success in employing selpercatinib to treat a 62-year-old man with ectopic Cushing’s syndrome due to medullary thyroid carcinoma (MTC). The case report, published in Current Oncology, notes that the patient’s Cushing’s features had resolved after 6 months of treatment. After another 6 months, his s-calcitonin had normalized and there was…

Ultrasound detail

Radiomics Features Differentiate MTC From PTC Nodules

Different radiomics features can help differentiate between medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) nodules of different sizes, according to a new study published in Clinical Medicine Insights: Oncology. Analyzing different combinations of radiomics features can lead to better diagnostic efficiency compared to single radiomics features and is a more reliable approach for…

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