Broader screening for pathogenic or likely pathogenic variants associated with endocrine tumor syndromes allows the detection of people at risk of developing the diseases, according to a new study published in BMC Medicine. Screening also results in the uptake of risk management and facilitates relevant diagnoses. “Further research will be necessary to continue to determine…
Everolimus plus long-acting release pasireotide (pasireotide-LAR) has promising efficacy compared to a single agent for the treatment of radioiodine-refractory differentiated thyroid cancer and medullary thyroid carcinoma (MTC), according to the results of a randomized phase 2 clinical trial that was published in Cancers. The aim of the trial was to assess the clinical efficacy and…
Researchers have discovered that external beam radiation therapy (EBRT) is a valuable tool in managing patients with thyroid carcinomas, according to a study published in Cancer Reports. The incidence of thyroid carcinomas has risen in recent years. They are histologically categorized into medullary thyroid carcinoma (MTC), differentiated thyroid carcinoma (DTC), and anaplastic thyroid carcinoma (ATC). …
A new study has found gastrointestinal adverse effects to be more common with selpercatinib for medullary thyroid cancer (MTC) than previously thought. The study, published in the Journal of Clinical Endocrinology & Metabolism, noted that the effects were generally self-limiting but required dose adjustments. “During [the LIBRETTO-001 clinical trial], as an international site, we observed…
A rare case of co-occurring medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) is described in a study published in the Open Journal of Pathology. MTC and PTC have different tissue origins and clinicopathological manifestations and rarely occur in the same patients, the authors wrote. The 44-year-old female patient had MTC on the left…
The American College of Radiology (ACR) score is best for differentiating between malignant thyroid nodules and benign nodules and between medullary thyroid carcinoma and papillary thyroid carcinoma, according to a new study. It is followed ex aequo by the ACR Thyroid Imaging Report and Data System (TI-RADS) and the Kwak TI-RADS, the researchers found. The…
Researchers reported that patients with multiple endocrine neoplasia type 2 (MEN2) and medullary thyroid carcinoma (MTC) experience psychosocial burdens such as pain affecting their daily life, as well as difficulties in concentrating, as published in Children. MEN2A and MEN2B are often associated with MTC, which is a chronic and indolent disease that can progress without…
Three metabolites could help differentiate patients with medullary thyroid carcinoma (MTC) from healthy individuals, according to a new study published in Scientific Reports. These are linoleic acid, linolenic acid, and leucine, and they can potentially be used as tumor biomarkers for the early detection of MTC. The metabolites were identified through the metabolomics profiling of…
A new case report demonstrates success in employing selpercatinib to treat a 62-year-old man with ectopic Cushing’s syndrome due to medullary thyroid carcinoma (MTC). The case report, published in Current Oncology, notes that the patient’s Cushing’s features had resolved after 6 months of treatment. After another 6 months, his s-calcitonin had normalized and there was…
Different radiomics features can help differentiate between medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) nodules of different sizes, according to a new study published in Clinical Medicine Insights: Oncology. Analyzing different combinations of radiomics features can lead to better diagnostic efficiency compared to single radiomics features and is a more reliable approach for…
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