A new personalized electroceutical device called Faremus has been shown to be a feasible, safe, and effective home-based method to reduce fatigue in patients with multiple sclerosis (MS), as published in Multiple Sclerosis and Related Disorders.

The medical device phase 2 study reports the use of an adapted version of the Faremus device at home, which consists of personalized transcranial Direct Current Stimulation (tDCS) used for 15 minutes per day for 5 days.

“Our specific strategy originates from the findings in fatigued patients who show an altered hyperexcitable profile in the primary motor cortex (M1) together with a hypoexcitable profile in the primary somatosensory cortex (S1), along with an alteration of the functional connectivity between the temporo-parietal hemispheric homologs and a generally reduced connectivity between S1 and M1,” the authors said.

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“In two independent randomized controlled trials (RCTs), we observed efficacy against MS fatigue of a personalized transcranial [tDCS] directed anodically to the bilateral whole body primary somatosensory area.”

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The Faremus tDCS system has been used in clinics and has been shown to be easy to use as well as free of side effects. The research team’s intention was to assess the feasibility, acceptance, and efficacy of such a remotely controlled system for use in 15 patients’ homes.

The patients were provided with training, monitoring, written instructions, and a telephone contact support system in case of problems. The treatment was applied once a day and lasted for 5 days, and all of the patients completed the treatment.

Three years later, the patients were contacted at home and were asked to recall their experience with the Faremus. They reported positive effects from the treatment, and no side effects, although the effects did not last very long. They recalled some difficulty with the procedures required.

The short duration of the effects suggests that it might be particularly useful to have a home-based version that patients can use on-demand. The authors conclude that the Faremus device offers a user-friendly and effective treatment against MS fatigue, with significant potential as an at-home device with remote clinical support.


Tecchio F, Cancelli A, Pizzichino A, et al. Home treatment against fatigue in multiple sclerosis by a personalized, bilateral whole-body somatosensory cortex stimulation. Mult Scler Relat Disord. Published online April 17, 2022. doi:10.1016/j.msard.2022.103813