A new study testing the exercise tolerance of patients with long-chain fatty acid oxidation disorder (LCFAOD) is now open.

The prospective case-control observational study sponsored by Academisch Medisch Centrum at the University of Amsterdam will compare the exercise tolerance of patients with LCFAOD with that of body mass index, sex, age, and physical activity score-matched healthy volunteers. 

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Investigators will use cardiopulmonary exercise tests and monitor the activity of participants over a 7-day period to measure their exercise capacity.

The hypothesis is that patients with LCFAOD will have greater oxygen debt during short periods of exercise compared to healthy volunteers.

The primary objective is to quantify exercise intolerance in patients with LCFAOD and to determine the relationship between the exercise intolerance that is measured and symptoms reported by patients, known markers of disease severity, and daily life functioning.

The secondary objectives are to determine the cause of exercise intolerance and whether the intermittent exercise protocol can be used to understand the course of exercise intolerance and provide a clinical outcome measure that could be used in future interventional studies.

“These findings will contribute to a better understanding of exercise intolerance in patients with LCFAOD and may guide the development of targeted interventions, such as exercise training programs and enable the analysis of effectiveness of new treatments,” the researchers said.  

The study that is expected to start on August 1, 2023, is not yet recruiting participants. It will take place at Amsterdam Medical University in the Netherlands and aims to enroll 50 participants, who are at least 18 years of age. The estimated completion date is August 1, 2028.

LCFAOD is group of genetic disorders in which the body is unable to use long-chain fatty acids as a source of energy. One of the main symptoms of LCFAOD is exercise intolerance reported in adult patients with the disease.


Exercise intolerance study in long chain fatty acid oxidation disorders (EXCITE LcFAOD). US National Library of Medicine. Updated June 29, 2023. Accessed July 27, 2023