Prediction equations used to estimate resting and total energy expenditures in individuals who are obese or overweight seem to be valuable in estimating energy expenditure in patients with long chain fatty acid oxidation disorders (LCFAODs) who are obese or overweight, according to a new study being presented at the Genetic Metabolic Dietitians International 2022 Educational Conference being held between May 4, 2022, and May 7, 2022.
“However, standard equations slightly overestimate energy expenditure in normal weight subjects,” the authors of the study wrote. “Total body composition does not differ between subjects with an [LCFAOD] and the normal population suggesting that slightly lower energy expenditure may be inherent to a diagnosis of an [LCFAOD].”
The treatment of LCFAOD focuses on reducing the attempted catabolism of fatty acids by the body and patients must follow a strict diet low in long-chain fatty acids and supplement with medium-chain triglycerides. It is not known whether the resting and total energy expenditure in patients with LCFAODs are similar to that of the general population.
Read more about LCFAOD diet
Here, a team of researchers led by James P. Delany, PhD, senior investigator at the Translational Research Institute for Metabolism & Diabetes in Orlando, Florida measured the resting and total energy expenditure as well as body composition in 32 patients with LCFAODs, aged 7 to 64 years, 53% of whom were obese or overweight. They then compared the measured values to estimated values.
They found that the estimated basal energy expenditure was higher than the measured resting energy expenditure among the patients. However, there was no difference between estimated and measured total energy expenditures.
The researchers also found that measured resting and total energy expenditures were significantly lower in patients with LCFAOD who were normal weight compared to estimates. However, the resting and total energy expenditures were not different among patients with LCFAODs who were obese or overweight compared to estimates.
Gillingham MG, Gregor A, Vockley J, Harding CO, DeLany JP. Resting and total energy expenditure of patients with long-chain fatty acid oxidation disorders (LC-FAODs). Poster presented at: Genetic Metabolic Dietitians International 2022 Educational Conference; May 4-7 2022; Lake Las Vegas, NV. Poster 15.