Researchers compared the impact of hemophilia on 2 age groups of male patients, 40-49 years and ≥50 years, in terms of comorbidities, health-related quality of life, and health care utilization, as published in the Journal of Blood Medicine.

They found that older patients with hemophilia had more mild or moderate disease, but they had reduced health-related quality of life and more comorbidities, including aging and hemophilic arthropathy, and they had lower health care utilization.

“These results, coupled with the important finding of a high rate of depression and anxiety in both age groups, highlight the need for special attention to be paid to [people with hemophilia],” the authors wrote.

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“The increasing survival rates among [people with hemophilia] reveal a growing array of physical, social, and mental health vulnerabilities requiring the attention of clinicians, caregivers, advocates and health-care policymakers.”

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The data obtained were based on those collected as part of the Hematology Utilization Group Studies VII study, which focused on patients aged 40 and older. A total of 70 men with hemophilia were included in the surveys and 57 completed the follow-up survey.

The patients completed several questionnaires on personal characteristics, self-reported comorbidities and complications, joint pain and health, work productivity and activity impairment, anxiety and depression, healthcare utilization, and health-related quality of life.

The authors note that the older patients were more likely to have mild or moderate disease, perhaps because of premature death among those with more severe disease. Also, the older cohort was born before manufacturing processes had been established to eliminate HIV and Hemophilia Treatment Centers from hemophilia medications.

The results of the study reveal an array of physical, social, and mental health issues among the growing number of long-term survivors of hemophilia, meaning there is an increased need for individualized services for these patients from clinicians, caregivers, and health care policymakers.


Curtis R, Manco-Johnson M, Konkle BA, et al. Comorbidities, health-related quality of life, health-care utilization in older persons with hemophilia—Hematology Utilization Group Study part VII (HUGS VII). J Blood Med. Published online May 9, 2022. doi:10.2147/JBM.S354526