A new study on men with hemophilia in Canada reports that although treatment has improved substantially, hemophilia is still associated with higher acute care utilization than among the general population. The study, published in Haemophilia, highlights the significant disease burden on patients with the disease.

“Because of the rarity of the disease and availability of data elements not routinely collected in national patient registries, population-based administrative database can be very useful in assessing the burden of disease in hemophilia,” the authors wrote.

“We aimed to determine the prevalence of men with hemophilia in Alberta, a Canadian province, using administrative data and evaluate mortality, comorbidities and health service utilization in this population compared to age-matched general male population.”

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The research team conducted a population-based, retrospective cohort study on 198 men with moderately severe hemophilia and 329 with mild/moderate hemophilia between 2012 and 2019. The cohort was age-matched with male general population controls.

The authors compared the prevalence of comorbidities, all-cause mortality, and care service utilization, and they applied logistic regression with the aim of identifying hospitalization predictors.

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The results showed that patients with all types of hemophilia had higher rates of hypertension, liver disease, and malignancies than those in the control group. Those with moderately severe hemophilia were hospitalized more often and had more Emergency Department visits and intensive care admissions. Those with multiple comorbidities and an age over 65 years were at higher risk of hospitalization.

The authors commented that, although hemophilia care has improved significantly along with personalized prophylaxis regimens, individuals with hemophilia in Canada continue to use health care services at a higher rate than age-matched controls. They hope that further advances in treatment options, personalized prophylaxis, and improved care access will ultimately reduce the high treatment and economic burden on both the patients and the health care system.


Alam A, Goodyear MD, Wu C, et al. Increased acute care utilisation, comorbidities and mortality in adults with haemophilia: A population-based cohort study from 2012 to 2019. Haemophilia. Published online October 20, 2022. doi: 10.1111/hae.14680