COVID-19 vaccination does not appear to increase hereditary angioedema (HAE) attacks, regardless of the type of vaccine, according to a study published in Ingenta Connect. 

A number of reports suggest that COVID-19 vaccines adversely impact patients with certain chronic diseases. Therefore, the authors of this study sought to investigate the influence of COVID-19 vaccination on HAE disease course. 

To carry out their study, the researchers determined the COVID-19 vaccination status of 140 adult patients with HAE. They also evaluated the number and severity of attacks 1 month before patients received their first COVID-19 vaccine dose, the period between the first and second dose (and third dose for patients who received 3 doses), and 1 month after the last vaccine dose. These were assessed using the disease severity score and the 10-point visual analog scale. 

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Among the 140 patients, 114 received at least 2 doses of COVID-19 vaccines, while 26 did not receive any vaccination. All patients received either the Sinovac or the Biontech vaccines, which were the only vaccines approved for use in Turkey, where this study was conducted. 

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“It seems that COVID-19 vaccination does not increase HAE attacks regardless of the type of the vaccines,” the authors wrote. 

Nevertheless, the research team recommends that HAE activity be under control before patients are given COVID-19 vaccinations. In addition, patients should be properly informed about the safety/risks of COVID-19 vaccines. 


Oztop N, Demir S, Toprak ID, Unal D, Gelincik A. Positive perception of COVID-19 vaccination in HAE: no significant impact of vaccination on disease courseAllergy Asthma Proc. 2022;43(6):546-554. doi:10.2500/aap.2022.43.220069