Laparoscopic resection (LAP), endoscopic full-thickness resection (EFR), and endoscopic submucosal dissection (ESD) are all safe and effective for gastrointestinal stromal tumors (GISTs), but EFT and ESD offer certain advantages, according to a new study published in Evidence-Based Complementary and Alternative Medicine.

Less trauma, shorter recovery time and hospital stay, and reduced costs were all advantages of EFT and ESD, the authors said.

“The effectiveness and safety of [LAP], [EFR], and [ESD] have been confirmed,” they wrote. “By observing 105 GIST patients and analyzing the application of different surgical methods, our doctors hope to improve the quality of life of patients and provide theoretical reference for the optimization of clinical medical work.”

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The research teams reviewed the clinical data on 105 patients with nonmetastatic or recurrent GISTs smaller than 6 cm undergoing surgery at a single center between March 2019 and March 2021. Patients were assigned to 1 of 3 groups: LAP (n=20), EFR (n=27) and ESD (n=58).

The results showed no significant differences between the groups in terms of complete resection rates, complication (bleeding and perforation) rates, survival, recurrence, or metastasis. All 3 methods had good efficacy, safety, and prognosis. However, both EFR and ESD resulted in improved recovery times, shorter hospital stays, reduced costs, and less trauma for the patients.

The authors recommend selecting the surgical approach based on tumor size and location, the surgical experience of the treating physician, and the patient’s preferences. They also recommend larger studies comparing these modalities, given the number of cases included was relatively small.


Jinyan Wu, Boneng Mao, Tao Jin, et al. Comparative study on the clinical effects of different surgical methods in the treatment of gastrointestinal stromal tumors. Evid Based Complement Alternat Med. Published online July 21, 2022. doi:10.1155/2022/1280756