Researchers determined that malnutrition risk and incidence among patients with gastrointestinal stromal tumors (GISTs) may increase during hospitalization and increase the risk of poor clinical outcomes, as published in Frontiers in Nutrition.

They retrospectively assessed the clinical data of 413 patients who underwent surgical resections for GISTs between 2016 and 2020 and found a clear correlation between malnutrition, malnutrition risk, and clinical outcomes.

“There are a large number of published studies showing malnutrition in surgical patients after discharge, which will affect the quality of life of patients and lead to delayed postoperative treatment and increased mortality,” the researchers wrote. “Therefore, attention to malnutrition in GIST patients will be particularly important for improving quality of life and significantly prolonging the survival period.”

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To assess the nutritional status at admission and again at discharge, all patients completed the Nutritional risk screening 2002 (NRS2002) and Patient-Generated Subjective Global Assessment (PG-SGA) within 24 hours of admission and discharge. Anthropometry (body weight, grip strength, and upper arm circumference) and serum biochemical parameters were also assessed at these time points.

The research team observed an overall increase in the patients’ malnutrition risk rate and malnutrition incidence during hospitalization, as well as a decrease in serum albumin, prealbumin, and total protein. They also found a decline in the anthropometric measures, particularly among the high-risk group.

Additionally, they found that the incidence of surgical-related complications was significantly higher in the patients with malnutrition than in patients without it, emphasizing the importance of nutritional status to achieving good postoperative outcomes among these patients.

The authors recommend dynamic monitoring of nutrition-related indicators including NRS2002 nutritional screening and PG-SGA perioperatively in patients with GISTs, in addition to providing appropriate nutritional support.


Ding P, Guo H, Sun C, et al. Relationship between nutritional status and clinical outcome in patients with gastrointestinal stromal tumor after surgical resection. Front Nutr. 2022;9:818246. doi:10.3389/fnut.2022.818246