A new prognostic nomogram developed by Chinese researchers can satisfactorily predict survival following surgery in patients with a gastrointestinal stromal tumor (GIST). The new nomogram could assist clinicians when evaluating the postoperative status of their patients and guide subsequent treatment decisions.

To develop the nomogram, a team of researchers led by Jie Li, of the Guang’anmen Hospital in Beijing, China, used postoperative data from 2000 to 2018 in the Surveillance, Epidemiology, and End Results Program database. 

The study is published in the journal BioMed Research International.


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The team divided the patients into 2 groups at random as the training and validation groups. They screened for prognostic factors and established the nomogram, the predictive performance of which they then tested. 

The independent prognostic risk factors associated with cancer-specific survival were age, race, and the location, size, grade, and stage of the tumor. 

Read more about the prognosis of GIST

The researchers also included the mitotic rate and chemotherapy when constructing the nomogram. 

The team then confirmed the robustness, predictive and discriminative ability, and clinical usefulness of the nomogram based on different parameters.

When they divided the patients into 3 groups—high, moderate, and low risk, based on the nomogram—they found significant differences between groups in terms of prognosis. 

“Our nomogram satisfactorily predicted survival in postsurgical GIST patients,” the researchers concluded. “Given its increased accuracy, good clinical utility, and more precise prognosis prediction compared with those of conventional risk classifications, our nomogram may be used to predict cancer-specific survival in patients with GISTs following surgery.”

GIST is a rare type of soft tissue tumor arising from the interstitial cells of Cajal situated in the wall of the gastrointestinal tract. The 5-year survival rate for GIST ranges between 32% and 93%, depending on staging and other factors.

Reference

Sun Q, Chen Y, Li T, et al. Prognostic nomogram for gastrointestinal stromal tumors after surgery based on the SEER database. Biomed Res Int. 2022;14;2022:5639174. doi:10.1155/2022/5639174