Endoscopic resection (ER) of gastric gastrointestinal stromal tumors (GISTs) may reduce postoperative recovery time compared to laparoscopic resection (LAP), according to a retrospective study published in Frontiers in Oncology.

In the study, patients who received ER had a statistically shorter postoperative fasting time (4.45 days vs 5.40 days; P =.013 and postoperative hospital stay (7.72 days vs 10.01 days, P <.001) compared to those who received LAP.

“Endoscopic resection treatment is safe and feasible for primary gastric stromal tumors with a diameter of 2 to 5 cm, and further research needs to be confirmed by multicenter prospective trials,” the authors said.

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The initial sets of patients included in the study had no statistical difference in age, gender, and tumor location; however, the tumors in the LAP group were statistically larger than those in the ER group (27.59 mm vs. 33.24 mm; P <.001). Following propensity score matching, there was no longer a significant difference between tumor sizes.

Meanwhile, the postoperative fasting time (4.18 days vs 5.16 days; P =.042) and postoperative hospital stay (7.12 days vs 9.94 days; P <.001) were still significantly shorter in the matched ER group than the matched LAP group.

A total of 197 patients with GIST were included in the retrospective study originally (74 ER and 123 LAP) between January 2011 and January 2018. The propensity-matched groups included 49 ER and 49 LAP patients.

During an average postoperative follow-up of 55.12 months, there was no significant difference between the number of recurrences in the 2 matched groups (1 ER vs 1 LAP). In terms of postoperative imatinib therapy, 1 ER patient and 5 LAP patients in the matched groups received treatment.


Li DL, Zhou YY, Zhang JY, Liu D, Zhao LX, Liu BR. Laparoscopic resection is not superior to endoscopic resection for relative small gastric gastrointestinal stromal tumors: a propensity score-matched study. Front Oncol. Published online October 13, 2022. doi:10.3389/fonc.2022.1015916