GIST News Briefs

Long-Term Survival of Patients With GISTs Similar With Endoscopic Resection and Surgery

A new study published in Surgical Endoscopy reported that local endoscopic resection and open, or laparoscopic, surgical resection resulted in similar long-term survival of American patients with gastric or colorectal gastrointestinal stromal tumors (GISTs).  This is the first large population-based study to compare endoscopic resection with surgical resection with a relatively long follow-up period. Addressing…

Experts Recommend Surgical Resection for GISTs Between 2 cm and 5 cm

A team of Chinese researchers, when comparing surgical resection to endoscopic resection for patients with gastrointestinal stromal tumors (GISTs) between the sizes of 2 cm and 5 cm, found that surgical resection outperformed endoscopic resection, according to a study published in Frontiers in Oncology.  The debate between the utility of surgical resection vs endoscopic resection…

GIST therapies

Pimitespib May Prevent GIST Progression in Some Patients

Pimitespib effectively inhibits in vivo tumor progression in a mouse model of gastrointestinal stromal tumor (GIST) with a germline KIT-Asp818Tyr mutation, according to a new study published in Experimental and Molecular Pathology. This result suggests that pimitespib might also control the progression of multiple GISTs in patients with germline KIT-Asp820Tyr mutations.  “Although careful observation may…

Liver Transplantation Still Rarely Used to Treat Unresectable GIST Metastases

Liver transplantation (LT) has rarely been used to treat unresectable gastrointestinal stromal tumor (GIST) metastases, according to a comprehensive literature review recently published in the International Journal of Surgery. “Although its [LT] application has a solid theoretical basis, its use understood as a radical extension of a standard resection can only be recommended within prospective…

New GIST Subtypes Identified Based on Long Noncoding RNA Signature

Researchers from China identified 4 molecular subtypes of gastrointestinal stromal tumor (GIST) with distinct biological pathways and clinical characteristics based on long noncoding RNAs (lncRNAs). They published their results in PeerJ. According to the authors, this lncRNA-based classification for GIST “may provide a molecular classification applicable to individual GIST” and has implications in terms of…

Treatment of GIST

Potential New Biomarker of GIST Malignancy and Prognosis Identified

High levels of fatty acid-binding protein (FABP) 4 might be indicative of malignant phenotype and poor prognosis in gastrointestinal stromal tumor (GIST), according to a new study published in the Journal of Clinical Laboratory Analysis.  Complete radical resection is the standard of care for localized GISTs, but some patients cannot have surgery due to late-stage…

GIST

New Sequencing Technique Provides Useful Biomarker for GIST Monitoring

A new sequencing technique detecting circulating tumor-DNA (ctDNA) may be useful for monitoring gastrointestinal stromal tumor (GIST) activity and treatment resistance, according to a study published in Molecular Cancer Therapeutics. Researchers used a sequencing strategy based on the SiMSen-Seq technique to detect tumor-specific and tyrosine kinase inhibitor (TKI) resistance mutations in plasma samples of GIST…

Ripretinib Receives Favorable Opinion as Treatment for Advanced GIST

The use of ripretinib (Qinlock®) for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who were previously treated with 3 or more kinase inhibitors received a favorable opinion from the European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP). Steve Hoerter, president and chief executive officer of Deciphera Pharmaceuticals,…

GIST

In Very Rare Cases, GIST and Liposarcoma Appear Concurrently

A literature review and case study published in the International Journal of Surgical Oncology reports 5 cases of concurrent gastrointestinal stromal tumor (GIST) and intra-abdominal liposarcoma. Although GIST quite frequently occurs at the same time as other malignancies, its coexistence with liposarcomas, which are also of mesenchymal origin, is extremely rare.  “Although coincidence may be…

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