A clinical trial aiming to determine the neuropsychological profiles of children with Duchenne muscular dystrophy (DMD) and their effects on motor function is currently taking place at Hacettepe University in Ankara, Turkey.

The prospective case-control study sponsored by Hacettepe University started on May 11, 2022, and it is expected to be completed on March 1, 2023. 

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The trial is comparing the neuropsychological profiles of patients with DMD, aged 7 to 16 years, to those of their typically developed peers, and it is investigating the effects of neuropsychological profiles on the participants’ motor functions. 

The cognitive function of all participants will be evaluated using the Modified Mini-Mental Test and the Controlled Oral Word Association Test, as well as the Central Nervous System Vital Signs test. 

Their neurodevelopmental status will be evaluated using the Conners’ Parent Rating Scale to assess any attention-deficit/hyperactivity disorder, the parent-reported Child Behavior Checklist to assess adaptive and problem behaviors, and the self-reported Strengths and Difficulties Questionnaire, which is a brief emotional and behavioral screening questionnaire.

Patients with DMD will also be evaluated in terms of motor function using the Brooke Lower Extremity Functional Classification to determine the functional status of their legs; the 32-item Motor Function Measurement, which was developed to assess motor function and progression of weakness in neuromuscular disorders; the 4-Square Step Test, which tests the ability to step over objects forward, sideways, and backward to assess dynamic balance and coordination; the 6-Minute Walk Test to evaluate the walking function and physical capacity of the patients; and timed performance tests including the 10-Meter Walk and Run Test, Gower’s sign, right and left leg standing, and the ascent and descent of 4 steps.

The study is active but is not currently recruiting participants. 


Neuropsychological profiles of children with Duchenne muscular dystrophy and its effects on motor functions. ClinicalTrials.gov. December 22, 2022. Accessed January 12, 2023.