A new study identified age, race, surgical resection, radiation, and chemotherapy as prognostic factors for diffuse large B-cell lymphoma (DLBCL) developing in the brain.

“This is the first study to demonstrate the effect of demographic and clinical features of patients with CCSV-DLBCL [cerebrum, cerebellum, brain stem, and ventricle DLBCL] on outcome prediction,” the study’s authors wrote in the Asian Journal of Surgery.

Results from multivariate analysis suggested that advanced age and Black ethnicity were poor prognostic factors for DLBCL developing in the brain.

Univariate analysis showed that patients aged 75 years and older had worse overall survival (OS) and disease-specific survival (DSS) than patients under 75 years, whereas patients aged between 45 and 60 years had the best survival outcomes in the study. Patients aged between 60 and 75 years had similar survival outcomes to those younger than 45 years. Black participants had worse OS and DSS than White participants or participants from other racial groups.

Patients who underwent surgical resection or received chemotherapy had longer OS than patients who did not have surgery or receive chemotherapy, respectively.

On the other hand, results for radiotherapy differed between univariate and multivariate analysis. Multivariate analysis suggested that radiotherapy improved OS and DSS, whereas univariate analysis did not.

The authors did not find statistically significant differences in OS and DSS when considering gender groups or different disease stages.

The study enrolled 1328 patients (mean age, 62 years) with DLBCL developing in the brain, in particular the cerebrum (54.22%), followed by the cerebellum (5.57%), from the Surveillance, Epidemiology, and End Results database. Most (84.41%) participants were classified at Ann Arbor stage I at presentation. More than half of patients received radiotherapy (51.58%) or chemotherapy (53.84%), while only 36.67% underwent surgery.


Zhou Z, Chen J. Survival and analysis of prognostic factors for primary diffuse large B-cell lymphoma of the brain. Asian J Surg. Published online December 17, 2022. doi:https://doi.org/10.1016/j.asjsur.2022.12.014