CC News Briefs

New Cholangiocarcinoma Noncoding RNA Could Become an Intervention Target

Proteasome 20S subunit alpha 3 antisense RNA 1 (PSMA3-AS1) represents a new cancer-promoting long noncoding RNA in cholangiocarcinoma, as published in Aging. This finding suggests that PSMA3-AS1 could be a target for the treatment of the disease. It is already known that long noncoding RNAs including PSMA3-AS1 play a crucial role in the development and…

Postoperative CA19-9 Shows Prognostic Significance in Cholangiocarcinoma

Researchers concluded that the levels of the carbohydrate antigen 19-9 (CA19-9) had a better prognostic performance in patients with intrahepatic cholangiocarcinoma when measured postoperatively, as published in Frontiers in Oncology. “Patients with elevated preoperative CA19-9 that normalizes after curative resection are associated with comparable long-term survival outcomes compared to those with normal preoperative CA19-9, whereas…

Conditional Survival Rates Vary Following Intrahepatic Cholangiocarcinoma Surgery

Conditional survival rates vary across stage categories in patients with nonmetastatic intrahepatic cholangiocarcinoma following surgery, according to a new study published in the Scandinavian Journal of Gastroenterology. This finding is important as it has implications in individualized clinical counseling and decision‐making for the disease. To examine the conditional survival rates of patients with nonmetastatic intrahepatic…

Photodynamic Therapy Shows Potential for Cholangiocarcinoma Cell Inhibition

Researchers from China demonstrated that photodynamic therapy (PDT) inhibited proliferation and promoted apoptosis in cholangiocarcinoma cells, as published in Biochemical and Biophysical Research Communications. The effects seemed to be partly mediated by the wingless-related integration site (Wnt) signaling. Mechanistically, the researchers showed that PDT decreased the expression of Wnt-7b, β-catenin, c-Myc, and cyclin D1 while…

Predicting Prognosis in Hilar Cholangiocarcinoma With Lymph Node Staging Systems

A Chinese team has found that for patients undergoing curative resection for hilar cholangiocarcinoma (HCCA), log odds of metastatic lymph nodes (LODDS) is the best of 4  lymph node staging systems with which to predict patient survival.  The study, which appeared in the Journal of Gastrointestinal Surgery, retrospectively compared commonly employed lymph node (LN) staging…

Ivosidenib Appears Active in Patients With Cholangiocarcinoma

Small-molecule inhibitors of mutated isocitrate dehydrogenase 1 (mtIDH1) enzyme such as ivosidenib are biologically active and well-tolerated in patients with solid and hematologic mtIDH1 malignancies such as cholangiocarcinoma, according to a new study published in Cancer Treatment Reviews. To broadly understand the activity of mtIDH1 inhibitors in patients with different cancers, a team of researchers…

Clear Panel Design Criteria Can Ensure Accuracy of LCFAOD Diagnosis

Researchers identified guidelines-consistent panels of 37 and 74 genetic conditions following evidence-based analyses of criteria, including long chain fatty acid oxidation disorders (LCFAODs) such as primary carnitine deficiency, carnitine palmitoyltransferase 2 deficiency, and very long-chain acyl-CoA dehydrogenase deficiency, as published in Genetics in Medicine. Other guideline-consistent conditions identified were sickle cell disease, cystic fibrosis (CF),…

New Model Has Potential for Early Detection of Cholangiocarcinoma

Researchers developed a new model that has great clinical potential for the detection of primary liver cancer and its subtypes including cholangiocarcinoma. The new method outperforms previous ones at a lower cost and is ultra-sensitive, as published in Hepatology. “Our model showed excellent performance for cancer detection in the test cohort,” the researchers wrote. It…

Minimally Invasive Right Hepatectomy Appears Promising for CCA

Researchers reported a minimally invasive right hepatectomy performed in a patient with perihilar cholangiocarcinoma (CCA), as published in Chirurgia (Bucur). “The goal of providing radical and curative-intent surgical treatment to patients with perihilar CCA has led to the definition of standard requirements to be fulfilled in surgical candidates including: biliary confluence resection combined with major…

ADC Values Can Help Differentiate Intrahepatic Cholangiocarcinoma

Apparent diffusion coefficient (ADC) values from diffusion-weighted imaging (DWI) magnetic resonance imaging may help with the differential diagnoses of intrahepatic cholangiocarcinoma (IHCC) and gastrointestinal system (GIS)-derived adenocarcinoma liver metastases, according to a new study published in Radiology and Oncology. The ADC values of patients with IHCC were significantly higher than those of patients with GIS…

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