CC News Briefs

petri dish

Novel Model Predicts Secondary Imatinib-Resistant GIST

Researchers from China developed a new model to predict secondary imatinib-resistant gastrointestinal stromal tumors (GISTs). Bioinformatic mining results of the study “provide potential and promising targets for imatinib-resistant therapy,” they said in a study published in the Scandinavian Journal of Gastroenterology. Imatinib is a drug that inhibits KIT signaling, which is involved in the pathogenesis…

infusion bottle

Drug-Eluting Beads With Systemic Therapy Shows Promise for CCA

The concomitant use of drug-eluting bead, irinotecan therapy (DEBIRI), and chemotherapy with gemcitabine/cisplatin may increase survival in patients with unresectable intrahepatic cholangiocarcinoma (CCA), according to results of a multicenter, randomized phase 2 clinical trial. Although the preferred approach to CCA is surgical resection, most patients are not eligible for surgery due to advanced disease progression.…

Biliary Surgery, SMAD4, and PBRM1 Predict Metastasis Risk in CCA

Mutations in SMAD4 and PBRM1 as well as a history of biliary surgery are all independent protective factors for metastasis in advanced cholangiocarcinoma (CCA), according to a new study published in the Journal of International Medical Research. The researchers also found that TP53 mutations were significantly more frequent in extrahepatic CCA and that mutations in…

MRI brain

Researchers Support Caudate Resection in Managing Perihilar CCA

Patients with perihilar cholangiocarcinoma (CCA) may have improved outcomes after receiving caudate lobe resection during curative surgical management, according to an article published in Annals of Surgical Oncology. In the systematic review and meta-analysis study, caudate lobe resection increased the likelihood of achieving margin-negative (R0) resection and improved overall survival (OS) without increasing perioperative morbidity.…

platelet

Mean Platelet Volume as a New Marker to Distinguish iCCA From HCC

Researchers discovered that mean platelet volume (MPV) is an independent factor in helping clinicians distinguish hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (iCCA), as published in BMC Gastroenterology.  HCC and iCCA are 2 cancers that share overlapping risk factors and clinical signs and symptoms, but strategies to treat either cancer remain different. Hence, it is vital…

ribosomal RNA

New Model Uses N6-Methyladenosine to Predict CCA Prognosis

Researchers developed a new model that could be a prognostic indicator for patients with cholangiocarcinoma (CCA) and published their results in BMC Cancer. “Our results provide evidence for the predictive prognosis of [CCA] and demonstrated that [tumor mutational burden] is not the only prognostic model that can be used to predict the prognosis for patients…

surgery

Preoperative Inflammatory Markers Show Prognostic Value in CCA

High preoperative values of inflammatory markers, specifically neutrophil to lymphocyte ratio (NLR), are associated with worse postoperative prognosis in patients with intrahepatic cholangiocarcinoma (CCA), a new study published in Cancer Medicine found. Although radical hepatectomy remains the most effective treatment for CCA, the short median survival after surgery produces the need to discover prognostic markers…

BMI

Body Composition Alterations Associated With Poorer Outcomes in CCA

Body composition alterations are highly prevalent in cholangiocarcinoma (CCA) and may be associated with lower disease free survival (DFS) and overall survival (OS), according to a study recently published in Hepatology Communications. Although unintentional weight loss is a classical feature of CCA, obesity tends to mask wasting signs in many CCA patients. However, assessment of…

gallbladder lining

Newly Identified Microbes Associated With Better Prognosis in CCA

Microbial relative abundance correlated with survival prognosis in patients with pancreaticobiliary cancers, including cholangiocarcinoma (CCA) and pancreatic adenocarcinoma, according to findings recently published in BMC Microbiology. Using 16 S rRNA gene amplicon sequencing, researchers analyzed the DNA of microbiota found in the bile collected from surgically resected gallbladders in 244 patients with pancreaticobiliary lesions treated…

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