Patients who had a lung transplant due to cystic fibrosis (CF) and needed at least 1 bronchoscopic intervention during the first year after the transplant had worse results in spirometry and 6-Minute Walk Test (6MWT) scores compared to those who did not need a bronchoscopic intervention. This is according to the results of a new study published in Transplant Proceedings.

However, regardless of the need for bronchoscopic intervention, patients benefit from lung transplantation, the authors of the study reported. Based on these findings, they concluded that “lung transplant should be performed in a timely manner and only among patients who have exhausted all other therapeutic options.”

To assess whether patients who needed a bronchoscopic intervention such as balloon dilatation, cryoprobe, argon plasma, and/or laser treatment have a lung function that is comparable with those who did not need any bronchoscopic intervention 1 year after the transplant, a team of researchers led by Marek Ochman, MD, PhD, conducted a retrospective study that analyzed 44 patients who had primary double lung transplant due to end-stage respiratory failure in the course of CF.

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The researchers found statistically significant differences between patients who required at least 1 bronchoscopic intervention and those who did not require any. These included differences in forced expiratory volume in 1 second (FEV1), FEV1 percent, Tiffeneau-Pinelli index, and percent oxygen saturation before and after the conclusion of the 6MWT.

The mean value for each parameter was lower in the first year for patients who needed at least 1 bronchoscopic intervention. The researchers also found a strong negative correlation between the number of balloons in the first year and the percentage FEV1 as well as the Tiffeneau-Pinelli index indicators after the first year.

Reference

Latos M, Urlik M, Nęcki M, et al. Influence of bronchoscopic interventions on graft function of double lung transplant recipients due to cystic fibrosis. Transplant Proc. Published online April 19, 2022. doi:10.1016/j.transproceed.2022.02.041