Chronic rhinosinusitis is a prevalent comorbidity in cystic fibrosis (CF) that can negatively impact the health-related quality of life in patients with the disease, according to a study published in the Journal of Cystic Fibrosis.

Studies have suggested that CF is associated with adverse outcomes in mental health. For example, depression is increasingly prevalent among patients with CF. The extent of psychological distress is best captured when patients agree to fill in various health-related quality of life questionnaires.

Most of the studies investigating the impact of CF on health-related quality of life parameters do so by investigating the effects of the disease as a whole, instead of breaking it down, symptom by symptom. In this study, Lee and colleagues wanted to investigate the impact on the quality of life of only one aspect of CF, chronic rhinosinusitis.

The research team recruited patients who were diagnosed with CF and who went through another round of testing for chronic rhinosinusitis. The candidates with CF and chronic rhinosinusitis (n=120) were then asked to fill in a number of health-related quality of life surveys.

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The results demonstrated that out of the 215 patients with CF, 120 patients (55.8%) had symptoms of chronic rhinosinusitis, suggesting that it is a fairly common comorbidity. Each survey was designed independently and had independent end-points; put together, they demonstrate that chronic rhinosinusitis has a negative impact on one’s health-related quality of life.

“The more severe the sinonasal symptoms are, the worse [health-related quality of life] was in our population,” Lee and colleagues wrote.

“The results of our study clearly demonstrate that the diagnosis and the severity of [chronic rhinosinusitis] can negatively impact the overall and CF-related [health-related quality of life] in CF patients, particularly within their physical health domains.” This study highlights the need to diagnose and manage chronic rhinosinusitis well in the care of patients with CF.


Lee DJ, Sykes J, Griffin K, Yao CMLK, Tullis E, Lee JM, et al. The negative impact of chronic rhinosinusitis on the health-related quality of life among adult patients with cystic fibrosis. J Cyst Fibros. Published online May 31, 2022. doi:10.1016/j.jcf.2022.05.008