CF News Briefs

sinuses

Study Highlights Need to Manage Sinonasal Symptoms in CF

Researchers reported that there was still a disparity between objective and patient-based measures of chronic rhinosinusitis in individuals with cystic fibrosis (CF) who were treated with highly effective modulator therapy, and published their findings in the International Forum of Allergy & Rhinology. One of the keys to boosting the quality of life in patients with…

Software developer

Proposed Bayesian Method Predicts Ventilation Distribution in CF

A new Bayesian method reduced the ventilation distribution in patients with cystic fibrosis (CF), as published in Respiratory Physiology & Neurobiology. This method used fewer breath cycles than lung clearance index (LCI) and correlated with ventilation magnetic resonance imaging (MRI), and was also important for clinical decision-making. Determining ventilation heterogeneity is essential because it is…

liver disease

Modified APRI Score as a Noninvasive Tool for Diagnosing CFRLD

Researchers discovered that the modified aspartate aminotransferase-to-platelet ratio index score (mAPRI) is a highly specific and noninvasive tool for the diagnosis of cystic fibrosis-related liver disease (CFRLD), as published in Clinical Transplantation. Despite the fact that liver disease is a significant cause of morbidity and mortality in patients with cystic fibrosis (CF), there is still no…

lung function test

PEP More Effective Than Usual Care for Lung Clearance in Cystic Fibrosis 

Positive expiratory pressure (PEP) is more effective than usual care or no intervention in patients with cystic fibrosis who are aged 16 or more years, according to a new study published in the journal Therapeutic Advances in Respiratory Disease. It is safe and has no adverse effects, researchers reported. However, there is not enough evidence…

serum levels

Oxidative Stress Elevated in CF, Increases With Time and Disease Severity

Patients with cystic fibrosis (CF) show elevated levels of oxidative stress in their serum, according to a study published in Antioxidants. These levels tended to increase with patient age and the severity of the disease. Elevated levels of both protein and lipid oxidation products were detected in patients with CF, compared to healthy controls, during…

IV feeding

Individualized Approaches Best for Boosting Nutritional Status of Patients With CF

Individualized high-quality carbohydrate diets, supplemented by pancreatic enzyme replacement therapy and enteric tube feeding if needed, can significantly improve the nutritional status of patients with cystic fibrosis (CF), according to findings published in Nutrition. The researchers conducted a systematic review of the literature from June 1, 2016, to March 14, 2021, to determine the most…

human lungs

Lung Transplantation Safe and Feasible for CF, Study Says

Double lung transplantation is a feasible treatment approach for end-stage lung disease due to cystic fibrosis (CF), according to a new study published in Transplantation Proceedings. Although this approach is technically challenging, the researchers found significantly better survival among transplant recipients with CF than among those with other underlying conditions. “The main goal is to…

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