Therapies targeting the pathogenic B-cell clone and the classical complement pathway have emerged as a new hope for treating cold agglutinin disease (CAD), allowing clinicians to choose between treatment approaches. In a new review article published in Transfusion Medicine Reviews, Sigbjørn Berentsen and Geir E. Tjønnfjord highlighted important differences between the B-cell-directed combination of bendamustine…
Although emergency and general measures for warm antibody autoimmune hemolytic anemia (AIHA) and AIHA due to cold agglutinin disease (CAD) are similar, specific therapies available for warm AIHA are not effective for CAD. Therefore, the preliminary identification of the type of antibody involved in each case is particularly relevant, according to a recently published article in Clinical…
Autoimmune hemolytic anemia (AIHA), one type of which is cold agglutinin disease (CAD), is usually considered a benign hematological disease. However, it is associated with high mortality in the intensive care unit (ICU) regardless of age and treatment, according to a recently published study in the American Journal of Hematology. According to several studies, AIHA has…
Two rare disease patients and a rare disease advocate will be the keynote speakers at the National Organization for Rare Disorders (NORD) 2022 annual rare disease conference, being held at the Marriott Marquis in Washington, DC, on October 17 and 18, 2022. NORD announced the keynote speakers as Brittany Clayborne, MS, PsyD, a post-transplant…
A rare occurrence of cold agglutinin disease (CAD) that accompanied a COVID-19 infection has been reported in a woman with the hemoglobin E (HbE) heterozygous phenotype. Findings from this case study were recently published in the Annals of Clinical Case Reports. Few case reports of autoimmune hemolytic anemia (AIHA), of which CAD is a type,…
Two patients with COVID-19 were found to have high cold agglutinin (CA) titers without presenting with hemolytic anemia or thrombosis commonly associated with cold agglutinin disease (CAD), according to a recently published article in the Journal of Clinical Laboratory Analysis. “Several studies of (cold agglutinin syndrome) associated with coronavirus disease 2019 (COVID-19) reported hemolytic anemia and…
Patients with cold agglutinin disease (CAD) may experience a recurrent decline in their quality of life, according to a study recently published in JMIR Formative Research. The study “highlights the importance and type of fatigue, seriousness of the disease as perceived by patients, impact of CAD even when no symptoms are experienced, and importance of…
A positive direct antiglobulin test is associated with enhanced anemia and the HLA-DR12 allele in patients from Japan, according to a new study published in Annals of Hematology. A positive direct antiglobulin test is also known to be related to SARS-CoV-2 infection, so a SARS-CoV-2 infection may cause the body to produce antiglobulins that attack…
Researchers revealed that the global vaccination against COVID-19 has led to the detection of autoimmune hematologic disorders such as cold agglutinin disease (CAD), as published in Vaccines. They noted that while these serious adverse events are rare, they can be life-threatening, and therefore rapid and accurate diagnoses are essential. “Vaccines against SARS-CoV-2, like other ones,…
The US healthcare system cannot keep up with the rapidly advancing field of gene therapy, experts who spoke at the 2022 World Orphan Drug Congress said.
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