The European Alliance of Associations for Rheumatology (EULAR) task force has conducted a systematic literature review and expert survey with the aim of updating the 2016 EULAR recommendations for managing antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The updated guidance, published in the Annals of Rheumatic Diseases, comprises 4 overarching principles and 17 recommendations. The new…
The persistence of proteinuria and hematuria after immunosuppressive induction therapy could have prognostic value in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), according to a new study published in Kidney International. The analysis of a large cohort of 571 patients with AAV identified persistent proteinuria after the induction ofremission as an independent predictor of death or…
Increased levels of immature and activated low-density granulocytes and altered degradation of circulating neutrophil extracellular traps (NETs) may contribute to the pathogenesis of granulomatosis with polyangiitis (GPA), a type of antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), according to an article published in the journal PLOS One. Researchers collected blood samples from 12 patients with GPA,…
A sizeable portion of individuals with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) experience fatigue severe enough to meet the diagnostic criteria for myalgic encephalomyelitis/chronic fatigue syndrome, according to a study published in The Lancet Regional Health — Americas. The authors of this study sought to assess fatigue in patients with AAV to see if it…
A patient with granulomatosis with polyangiitis, a form of antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), received long-term multidisciplinary treatment at an intensive care unit (ICU) due to massive hemorrhage and multisystem involvement, according to an article published in the Turkish Journal of Trauma and Emergency Surgery. The study authors reported on a 37-year-old male patient…
In patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and end-stage kidney disease (ESKD) who are receiving renal replacement therapy, higher rates of mortality and infection have been reported, along with a lower risk for relapse, according to findings from a meta-analysis published in Seminars in Arthritis and Rheumatism. Approximately 20% of patients with AAV…
The Canadian Vasculitis Research Network (CanVasc) has updated its consensus recommendations for the use of avacopan in patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). The guidelines, published in Rheumatology, are based on data confirming that avacopan is an effective steroid-sparing therapy for microscopic polyangiitis and granulomatosis with polyangiitis. “Prospective studies published between 2017 and…
A new study has identified 4 renal function trajectories in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), with over half of patients affected by renal manifestations. The study, published in Arthritis Care & Research, highlights the burden of chronic kidney disease (CKD) in this patient population. “Renal manifestations of AAV span a range of…
Patients with subtypes of small-vessel antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), including granulomatosis with polyangiitis and microscopic polyangiitis, as well as those with certain types of large-vessel vasculitis (LVV), may have elevated circulating levels of neutrophil-activating factors, according to an article published in Clinical Immunology. In this study, the researchers primarily assessed the levels of…
The global glomerulitis score could be a predictor of end-stage kidney disease (ESKD) in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with glomerulonephritis (AAV-GN), according to a preprint posted in Research Square. “This study is the first to show that global glomerulitis independently predicted the progression to ESKD in Korean patients with AAV-GN. Therefore,…
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