News

Latest News

Patients With IPF and GERD Showed Higher Risk for Poor Outcomes

There is an association between idiopathic pulmonary fibrosis (IPF) and gastroesophageal reflux disease (GERD), according to results published in Chest. The study is being presented virtually at the Chest 2021 Annual Meeting on Oct. 17-20, 2021. The association between IPF and GERD was already known possibly due to chronic micro-aspiration leading to lung parenchyma remodeling.…

Improved Motor Function With Nusinersen Observed in SMA Patients

Treatment with nusinersen (Spinraza®) improves motor function in adult and pediatric patients with type 2 and 3 spinal muscular atrophy (SMA), according to a new meta-analysis study published in the Orphanet Journal of Rare Diseases. All of the studies reviewed reported an increase in Hammersmith Function Motor Scale Expanded (HFMSE) for treated patients, and the…

Seven-Domain Framework Finds Poor Sleep Health in Many MS Patients

Results from a study examining sleep health in individuals with multiple sclerosis (MS) demonstrated that 76% of participants measured in extreme ranges for at least 2 of 7 sleep domains. Poor sleep quality affected 45% of participants, abnormal sleep timing affected 35%, and pathological daytime sleepiness affected 33%. Investigators calculated median values of 456.3 minutes…

GIST Recurrence Risk Higher With Certain KIT Exon 11 Mutations

A new study found that patients with certain types of mutations to exon 11 of the KIT gene are at increased risk of recurrence for gastrointestinal stromal tumor (GIST) after complete resection. The study was published in Therapeutic Advances in Medical Oncology. The results demonstrated that 18 out of 36 patients (50%) with KIT exon…

AATD Testing in COPD Patients Remains Low Despite Clinical Benefits

Are we testing enough for alpha-1 antitrypsin deficiency (AATD) in patients who develop chronic obstructive pulmonary disease (COPD)? Rao and colleagues set out to investigate the answer to this question. They discovered that only 20.6% of COPD patients underwent AATD testing, despite the majority of physicians demonstrating awareness of the importance to test all newly…

Splicing Mutations as Potential Diagnostic Targets for ALGS

Alternative splicing has been implied in the development and progression of pediatric liver diseases such as Alagille syndrome (ALGS), according to a new review published in Frontiers in Molecular Biosciences. The current knowledge on ALGS etiology estimates that most patients (94%) have variants of the JAG1 gene. A smaller percentage (1%-2%) of patients present alterations…
Next post in IPF News Briefs