Pulmonary Arterial Hypertension Endothelin Receptor Antagonists
Excessive vasoconstriction and excessive cellular proliferation play important roles in the pathogenesis of pulmonary arterial hypertension (PAH). Endothelin-1 (ET-1) is a potent vasoconstrictor that also promotes the proliferation of pulmonary artery smooth muscle cells. Patients with PAH have elevated levels of plasma ET-1, which correlate with disease severity and prognosis. Furthermore, the clearance of ET-1…