Junction: Oncology

A Potential New Biomarker for the Prognosis of Intrahepatic Cholangiocarcinoma

The expression of dual-specificity phosphatase 11 (DUSP11) is associated with tumor infiltration and overall survival rate in intrahepatic cholangiocarcinoma, according to a new study published in Frontiers in Oncology. This was not the case for perihilar or distal cholangiocarcinoma.  The researchers summarized that DUSP11 is an independent biomarker of intrahepatic cholangiocarcinoma that is indicative of…

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GIST, Cholangiocarcinoma Groups Work to Educate Clinicians on Rare Cancers

Gastrointestinal stromal tumor (GIST) and cholangiocarcinoma are very different types of rare cancers, but they share a crucial trait: few people have ever heard of them. Even so, about 22% of all cancer cases diagnosed worldwide are considered rare, making them collectively far more common than breast cancer (16% of the total), colorectal cancer (15%),…

Antiparasitic Compound Could Hold Promise as Cholangiocarcinoma Treatment

Dithiazanine iodide is an antiparasitic compound that has anticancer properties in vitro and is associated with decreased mitochondrial electron transport protein expression, as well as cellular ATP depletion in cholangiocarcinoma cells, according to a poster being presented at the NORD Breakthrough Summit 2021. These results support the potential use of the compound as a therapy…

ACYP1 Expression Linked With Worse Outcomes in Hepatic Carcinomas

When investigating the clinical significance of acylphosphatase 1 (ACYP1) expression in hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), and combined hepatocellular and cholangiocarcinoma (cHCC-iCCA), a team of Japanese researchers discovered that ACYP1 expression influences tumor growth and cell viability in both HCC and iCCA and thus has an impact on prognosis. The finding was published in…

Carbohydrate Antigen 19-9 Biomarker Shown Useful for Distal CCA Prognosis

Higher presurgical ratios of carbohydrate antigen 19-9 (CA19-9) to γ-glutamyltransferase (GGT) were associated with tumor recurrence and worse long-term prognosis for patients with distal cholangiocarcinoma (CCA), according to a new study published in the World Journal of Gastrointestinal Surgery. The study found that patients with preoperative CA19-9/GGT ratios below 0.12 (group 1) had higher 1-,…

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