Junction: Oncology

insulin molecule

Newly Identified Metabolites Aid in Early Detection of MTC

Three metabolites could help differentiate patients with medullary thyroid carcinoma (MTC) from healthy individuals, according to a new study published in Scientific Reports. These are linoleic acid, linolenic acid, and leucine, and they can potentially be used as tumor biomarkers for the early detection of MTC. The metabolites were identified through the metabolomics profiling of…

thyroid cancer

MTC With Cushing’s Syndrome Successfully Treated With Selpercatinib

A new case report demonstrates success in employing selpercatinib to treat a 62-year-old man with ectopic Cushing’s syndrome due to medullary thyroid carcinoma (MTC). The case report, published in Current Oncology, notes that the patient’s Cushing’s features had resolved after 6 months of treatment. After another 6 months, his s-calcitonin had normalized and there was…

Ultrasound detail

Radiomics Features Differentiate MTC From PTC Nodules

Different radiomics features can help differentiate between medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) nodules of different sizes, according to a new study published in Clinical Medicine Insights: Oncology. Analyzing different combinations of radiomics features can lead to better diagnostic efficiency compared to single radiomics features and is a more reliable approach for…

thyroid cancer cells

Lactic Acidosis Promotes Aggressive Features in Cholangiocarcinoma

Researchers found an increase in cancer aggressiveness in cholangiocarcinoma (CCA) cells exposed to lactic acidosis due to the upregulation of ALDH1A3, as published in Life Sciences. The team derived information on ALDH1A3 expression in CCA cells from the Gene Expression Omnibus datasets. They also used several human CCA cell lines to demonstrate increased ALDH1A3 expression…

group

People With Rare Diseases Report Facing Stigma, Poor Quality of Life

People with rare diseases who live in the United States have a poor health-related quality of life and experience significant stigma, according to a study published in the Orphanet Journal of Rare Diseases. A rare disease in the United States can be defined as any disease in which the prevalence is less than 200,000 cases.…

Tumor necrosis

Proposed MTC Grading System Combines Proliferative Activity and Necrosis

The International Medullary Thyroid Carcinoma Grading System (IMTCGS) appears to be superior to other grading systems for predicting disease-free survival (DFS) and overall risk stratification in patients with medullary thyroid carcinoma (MTC), according to a study recently published in Endocrine Pathology. “We suggest the implementation of the IMTCGS scheme in routine clinical practice: one of…

Thyroid gland tumour

IMTCGS Grading System Is Reproducible in MTC, Study Says

Researchers reported that a grading system developed for medullary thyroid carcinoma (MTC) has prognostic value and is reproducible and published their findings in Endocrine Pathology. Medical researchers have recently focused on uncovering whether histological tumor grades of MTC correspond to prognosis in any way. Some researchers have started to develop new grading schemes for MTC…

Metastasis in the brain

A Rare Case of Calcitonin-Negative MTC With Metastasis

Researchers reported a rare case of calcitonin-negative medullary thyroid carcinoma (MTC) with brain metastasis in a 64-year-old man and found that although serum calcitonin and carcinoembryonic antigen (CEA) concentrations typically serve as biomarkers for MTC diagnosis, both were normal in this case. “We describe a case of metastatic MTC that, despite tumor positivity for calcitonin,…

clinical trial research

First Patient Enrolled in Trial Assessing SD-101 for Intrahepatic Cholangiocarcinoma

TriSalus Life Sciences has enrolled the first patient in its Pressure-Enabled Regional Immuno-Oncology (PERIO™-02) trial evaluating SD-101, a toll-like receptor 9 (TLR9) agonist for adults with locally advanced, metastatic, or unresectable hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICC). “Patients with advanced HCC or ICC often have limited options when seeking treatment, as checkpoint inhibitors have…

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