Junction: Immunology

NMOSD

Inebilizumab Reduces Asymptomatic Lesion Formation in Patients With NMOSD

New data from a phase 3 clinical trial showed that inebilizumab treatment reduced asymptomatic optic nerve lesion formation in patients with neuromyelitis optica spectrum disorder (NMOSD). This new finding was announced in a press release by Horizon Therapeutics, the developers of inebilizumab, and was also presented at the 49th Annual Meeting of the North American Neuro-Ophthalmology…

Coombs test blood sample

High Grades of DAT May Predict Severe Anemia in Patients with AIHA

There might be a significant association between high grades of direct antiglobulin test (DAT) results and the severity of anemia, hemolysis, and jaundice in patients with autoimmune hemolytic anemia (AIHA), both warm and cold types such as cold agglutinin disease (CAD), according to a study published in the Asian Journal of Medical Sciences. The researchers…

Human anatomy with lungs

Case Report: Autoimmune Hemolytic Anemia and Sarcoidosis

Researchers presented the case report of a patient who was diagnosed with autoimmune hemolytic anemia and sarcoidosis in Authorea. The healthcare providers in the case worked to determine whether the patient’s autoimmune hemolytic anemia could have been driven by cold agglutinins, such as in the case of cold agglutinin disease (CAD).  Sarcoidosis is often accompanied…

FDA sign

FDA Grants RMAT Designation to Novel HAE Medication NTLA-2002

The US Food and Drug Administration (FDA) granted Regenerative Medicine Advanced Therapy (RMAT) designation to NTLA-2002, an in vivo clustered regularly interspaced short palindromic repeats (CRISPR)-based investigational therapy designed to inactivate kallikrein B1 target gene and prevent swelling attacks in people with hereditary angioedema (HAE), Intellia Therapeutics announced. The designation is based upon the promising results from the…

facial recognition

3D Facial Analysis Technology Could Improve Diagnosis of HAE

Three-dimensional (3D) photogrammetry in association with Cliniface—an open-source software for facial analysis—could have a role in the diagnosis of hereditary angioedema (HAE), according to a study published in PLOS Digital Health. The authors of the study anticipate multiple benefits for the application of quantitative 3D facial imaging in analyzing the physiognomy of people with HAE,…

Galzin Wilson disease

Satralizumab Linked to Successful Tapering of Prednisolone in NMOSD

A new study published in Neurological Sciences has revealed that patients with aquaporin-4-positive (AQP-4 positive) neuromyelitis optica spectrum disorder (NMOSD) can taper prednisolone dose to less than 3 mg/day after receiving satralizumab. The case study found that satralizumab may be an effective option for patients with NMOSD, who want to reduce their steroid burden without compromising their…

NMOSD Prognosis

Accurate Patient-Reported Outcome Measures Needed for Optic Neuritis

Existing patient-reported outcome measures (PROMs) for optic neuritis in neuromyelitis optica spectrum disorder (NMOSD) and other disorders may not be sufficient, according to a study recently published in Eye. “There is unmet need for a PROM with strong content and psychometric development applicable to optic neuritis for use in virtual care pathways and clinical trials…

NMOSD

Dysautonomic Symptoms May Affect Quality of Life in NMOSD

Symptoms of autonomic dysfunction impact the quality of life of patients with neuromyelitis optica spectrum disorder (NMOSD) and were found to correlate with certain clinical characteristics in a study published in BMC Neurology. Scores on the Composite Autonomic Symptom Score 31 (COMPASS-31) were found to be significantly correlated with quality of life for patients with…

Blood transfusion

Case Report: 71-Year-Old Woman With Refractory Hemolytic Anemia

Clinicians presented the case of a 71-year-old woman who was diagnosed with refractory hemolytic anemia in The New England Journal of Medicine.  The patient had a 7-month history of fatigue and dyspnea, which worsened on exertion. She was on breast cancer follow-up and had diffuse cutaneous systemic sclerosis.  Blood investigations revealed anemia, and a peripheral…

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