Junction: Immunology


Antibody Status Impacts Disease Severity in MG

Patients with myasthenia gravis (MG) who are positive for a combination of both anti-acetylcholine receptor (AChR) and anti-Titin antibodies (AChR+Titin-MG) had more severe symptoms and progressed faster than patients with only anti-AChR (AChR-MG), and those with anti-AChR in combination with anti-low-density lipoprotein receptor-related protein 4 (LRP4) antibodies (AChR+LRP-MG), as published in Frontiers in Neurology. Patients…


Elevated Plasma C5a Levels Correlate With Pain in NMOSD

Researchers found elevated plasma levels of complement 5 (C5)-a and other inflammatory cytokines in patients with neuromyelitis optica spectrum disorder (NMOSD) during remission, as published in Neuropsychiatric Disease and Treatment. This is the first study to demonstrate the relationship between C5a levels in peripheral blood and pain in patients with NMOSD during remission, the authors…


People With Rare Diseases Report Facing Stigma, Poor Quality of Life

People with rare diseases who live in the United States have a poor health-related quality of life and experience significant stigma, according to a study published in the Orphanet Journal of Rare Diseases. A rare disease in the United States can be defined as any disease in which the prevalence is less than 200,000 cases.…

anxiety and depression

Patients Report Psychological and Physical Impact of Living With NMOSD

Symptom severity, pain, fatigue, depression, and work-related barriers caused by neuromyelitis optica spectrum disorder (NMOSD) strongly affect the quality of life in patients with the disease, according to a new study published in Neurology and Therapy. Researchers conducted an observational, multicenter, cross-sectional study in Spain from November 2019 to July 2020 to assess the impact…

MRI head scan

Lesion Location and Morphology Aid in NMOSD Diagnosis

Certain symptoms and abnormal findings in imaging studies may be useful to differentiate the first attack of neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS), according to a study recently published in Frontiers in Neurology. The authors registered demographic, clinical manifestations, Expanded Disability Status Scale (EDSS) scores, and head magnetic resonance imaging (MRI) findings…

iv drip

Potential CAD Treatment Appears Safe, Well-Tolerated in Healthy Adults

CAN106 is safe and well-tolerated in healthy volunteers, according to the results of a phase 1 clinical trial that will be presented at the European Hematology Association’s 2022 annual congress. Moreover, the treatment resulted in a dose-dependent reduction in free C5 and CH50 as well as a complete and sustained complement blockade for up to…

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