Treatment with anti-interleukin (IL)-17 may play a beneficial role in several subtypes of pustular psoriasis (PP), including generalized pustular psoriasis (GPP), according to findings from 3 case studies published in the journal Cytokine. Known to be a clinically heterogeneous disease entity that comprises a variety of subtypes, PP can be classified into 3 phenotypes: GPP,…
A new study has assessed the impact of a switch from tumor necrosis factor-alpha (TNF-α) inhibition to interleukin (IL)-17 inhibition using brodalumab on symptoms of depression and anxiety in patients with psoriasis, of which generalized pustular psoriasis (GPP) is a form. The study, published in the Journal of Dermatology, found significant improvements in the Psoriasis…
Dermatological diseases such as generalized pustular psoriasis (GPP) often result in considerable distress among patients due to their outward visibility. Such dermatological diseases burden the patient in two ways: the disease itself, which needs treating, and self-perception and self-esteem issues that can result in considerable psychiatric pathology. There is a dichotomy in medicine when it…
An open-label, multicenter, single-arm, postmarketing trial is set to evaluate the efficacy and safety of spesolimab as well as the impact of immunogenicity on the efficacy, safety, and pharmacokinetics of spesolimab, in patients with generalized pustular psoriasis (GPP) who have already received the drug and still experience recurrent flares. The study, set to start on…
Despite its distinctive clinical presentation, diagnosis of generalized pustular psoriasis (GPP) poses significant challenges for patients and physicians.
A case has been published of an elderly woman with impetigo herpetiformis, a variant of generalized pustular psoriasis (GPP), concurrent with SARS-CoV-2 infection and undergoing treatment with secukinumab. The case report, published in the Journal of Cutaneous Immunology and Allergy, reported that the patient had a heterogeneous c.28C>T (p.Arg10X) mutation in IL36RN, which is associated…
A recent study published in The Journal of Dermatology has concluded that the p.Pro82Leu variant of the IL36RN gene, discovered in an adult-onset generalized pustular psoriasis (GPP) patient with psoriasis vulgaris, is unlikely to exert a substantial influence on GPP development. “Considering our findings and the fact that the prevalence of GPP is not higher…
The presentation of generalized pustular psoriasis (GPP) is generally heterogeneous, according to a study published in Experimental Dermatology. Although GPP is best known for its recurrent flares of sterile pustules, various systemic complications and comorbidities may also be present. This creates a diagnostic challenge for physicians and can cause significant distress among patients. Existing studies…
Due to the rarity of generalized pustular psoriasis, cases often go unrecognized by physicians who are not dermatologists.
The results of a recent study published in the Journal of Investigative Dermatology could have significant implications for the interpretation of IL36RN variants in diagnostic settings, potentially leading to improved management and treatment strategies for patients with generalized pustular psoriasis (GPP). In addition, the study provides new insights into the structural elements that govern IL-36Ra activity,…
