As we look over the evolution of medicine, we see we have gone from what can be described as crude experimentation in ancient times to more sophisticated ways of managing the signs and symptoms of a disease in the past century. The effort to dig deeper through the layers of a disease to reach its…
The bromodomain-containing protein 9 (BRD9) was identified as a key molecule in the progression of gastrointestinal stromal tumors (GISTs), according to researchers from the Hospital of Jilin University, Changchun, China. The study was published in the journal Cell Death & Disease. BRD9 inhibition can be considered as a new therapeutic strategy in GISTs, used as…
A new retrospective study emphasized the importance of preoperative evaluation and frequent postoperative follow-up of gastrointestinal stromal tumor (GIST) patients. This study was published in the journal Medical Science Monitor. This close monitoring is particularly important in older male patients and patients with malignant comorbidities. “There is an association between tumor location, size, length of…
Gastrointestinal stromal tumor (GIST) and cholangiocarcinoma are very different types of rare cancers, but they share a crucial trait: few people have ever heard of them. Even so, about 22% of all cancer cases diagnosed worldwide are considered rare, making them collectively far more common than breast cancer (16% of the total), colorectal cancer (15%),…
The challenge for scientists is to develop immunotherapies targeting new molecular sites that can provide consistent clinical benefits in GIST patients.
A new study found that patients with certain types of mutations to exon 11 of the KIT gene are at increased risk of recurrence for gastrointestinal stromal tumor (GIST) after complete resection. The study was published in Therapeutic Advances in Medical Oncology. The results demonstrated that 18 out of 36 patients (50%) with KIT exon…
Researchers from Japan developed a predictive model for the diagnosis of gastrointestinal stromal tumors (GISTs). “Our predictive model will be a practical guide for the management of gastric subepithelial lesions,” they wrote in an article they published in the journal Medicine. Read more about GIST diagnosis. In order to develop their model, the team led…
A new study published in Surgical Endoscopy reported that local endoscopic resection and open, or laparoscopic, surgical resection resulted in similar long-term survival of American patients with gastric or colorectal gastrointestinal stromal tumors (GISTs). This is the first large population-based study to compare endoscopic resection with surgical resection with a relatively long follow-up period. Addressing…
The clinical management of metastatic gastrointestinal stromal tumor (GIST) has greatly improved since the early 2000s.
A team of Chinese researchers, when comparing surgical resection to endoscopic resection for patients with gastrointestinal stromal tumors (GISTs) between the sizes of 2 cm and 5 cm, found that surgical resection outperformed endoscopic resection, according to a study published in Frontiers in Oncology. The debate between the utility of surgical resection vs endoscopic resection…
