SM Clinical Trials
Features & Insights
Given the complexity of systemic mastocytosis, the disease is best managed in a multidisciplinary setting.
Many children and adults have few, if any, symptoms. When symptoms do occur, they are due to the diverse physiologic effects of secreted mast cell mediators, such as histamine, eicosanoids and cytokines.
Mast cell activation disorders are a heterogeneous group in which patients present with signs and symptoms of disease mediated by the synthesis and release of activation products such as reformed vasoactive amines, newly generated arachidonic acid derived mediators, and induced cytokines.
After countless colonoscopies and multiple steroid treatments, biopsies determined I had abnormally large counts of white blood cells.