Latest News
Case Report: A Rare Co-occurrence of ALGS and Von Willebrand Disease
Splicing Mutations as Potential Diagnostic Targets for ALGS
Researchers Identify New Source of Intrahepatic Duct Cells
Ultra-Widefield and Anterior-Segment OCT Useful in Alagille Syndrome
Case Study: Nonhepatic Alagille Syndrome With Cardiac Abnormalities
Craniospinal Manifestations in Alagille Syndrome Patients
FDA Approves First Treatment for Cholestatic Pruritus in Patients With Alagille Syndrome
Notch Signaling Affects Intrahepatic Duct Cell Regeneration in Alagille Syndrome
Study Suggests Environmental Factors Play a Role in Liver Diseases
Latest Clinical Trials
Features
Managing the Clinical Manifestations of ALGS: Hepatic and Cardiac Considerations
Pediatric gastroenterologist Henry Lin, MD, MBA, reviews how the liver and cardiac system are involved in Alagille syndrome.
Relieving the ‘Devastating’ Severe Itching Faced by Patients With Alagille Syndrome
Kristen Baugher knew shortly after giving birth to her daughter, Emmery, that something was wrong. Jaundiced and weak, the baby itched uncontrollably.
Israel Emerges as Global Powerhouse in Rare Disease Research
TEL AVIV, Israel — On the 6th floor of Schneider Children’s Hospital in the Tel Aviv suburb of Petah Tikva, 30 children with Alagille syndrome and 2 with lysosomal acid lipase deficiency (LAL-D) receive specialized treatment from a trio of pediatric hepatologists. Across town, at Sheba Medical Center’s Edmond and Lily Safra Children’s Hospital, pediatric…
Alagille Syndrome Alliance Leads Fight to Treat Rare Liver Disease
In August of 2003, Roberta Smith of East Tawas, Michigan, gave birth to twin daughters. It was immediately obvious that one of the girls, Cloe, was seriously ill. Jaundiced and plagued by incessant itching, the infant was diagnosed with Alagille syndrome 2 weeks later. Cloe’s disease is exceedingly rare, affecting roughly 1 in 30,000 to…
Where We Are in ALGS: A Pediatric Gastroenterologist’s Perspective
Although we are making headway in understanding and treating people living with Alagille Syndrome (ALGS) — a rare genetic disorder that manifests in a variety of ways — several questions remain. Here, Henry C. Lin, MD, pediatric gastroenterologist in the Division of Gastroenterology at Doernbecher Children’s Hospital, Oregon Health & Science University, shares his perspective…
ALGS Clinical Insights
Genome Sequencing Increases Diagnostic Accuracy in Alagille Syndrome
We explore the role of genomic sequencing in diagnosing Alagille syndrome and some of the dilemmas of genetic testing for this disease.
The Risk of Hepatocellular Carcinoma in Patients With Alagille Syndrome
In rare cases of ALGS, patients also develop hepatocellular carcinoma (HCC), with only about 30 cases being reported in the literature.
Differential Diagnosis of Central Hepatic Regenerative Nodules in ALGS
Pediatric and adult ALGS patients may sporadically present benign hepatic nodules, also known as regenerative or regenerating nodules.
Targeting Intrahepatic Bile Duct Paucity in Alagille Syndrome
Researchers at the University of Pennsylvania highlight the improvements in disease modeling afforded by a molecular understanding of Alagille syndrome.
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