Latest ALGS News
Atypical Focal Choroidal Excavation With a Macular Hole Reported in Patient With ALGS
Study Finds Maralixibat Improves Quality of Life for Children With Alagille Syndrome
Biomarkers of Liver Stiffness Investigated in Pediatric Cholestatic Liver Diseases
New Tool Developed to Assess Impact of Pruritus in Patients With Liver Diseases
A Case of Alagille Syndrome in a Neonate Diagnosed After Death
Biomarkers Can Differentiate Mitochondrial Hepatopathies From Other Liver Diseases
Surgery Effective in Treating Peripheral Pulmonary Artery Stenosis in ALGS
Researchers Identify Thresholds Associated With Liver Survival in Alagille Syndrome
Researchers Advise Better Oral Health Promotion in Rare Diseases Like ALGS and CF
Latest Clinical Trials
- Efficacy and Safety of Odevixibat in Patients With Alagille Syndrome (ASSERT)
- Long-term Safety and Efficacy of Odevixibat in Patients With Alagille Syndrome (ASSERT-EXT)
- A Maralixibat Expanded Access Program for Patients With Cholestatic Pruritus Associated With Alagille Syndrome (ALGS)
- Evaluation of LUM001 in the Reduction of Pruritus in Alagille Syndrome (ITCH)
- Safety and Efficacy Study of LUM001 (Maralixibat) With a Drug Withdrawal Period in Participants With Alagille Syndrome (ALGS) (ICONIC)
Insights
Improving the Timely Diagnosis of ALGS by Understanding Its Characteristic Features
Congenital genetic diseases sometimes display characteristic clinical manifestations that direct physicians to conduct the necessary tests to arrive at a correct diagnosis. However, other genetic diseases may be more insidious and are diagnosed only later in life (if at all), which means the early window for the initiation of critical medical intervention is missed. When…
A Rare Co-occurrence of Alagille Syndrome and von Willebrand Disease
In the South African Journal of Child Health, Dempster and colleagues detail the case of a patient who was simultaneously diagnosed with 2 rare disorders: Alagille syndrome and von Willebrand disease. A 17-year-old female patient presented with hypochromic anemia and splenomegaly. She had been diagnosed with Alagille syndrome in infancy due to having characteristic features…
Alagille Syndrome May Cause Significant Cardiac Anomalies, Even Without Liver Involvement
Although Alagille syndrome is a multisystem disease, occasionally it can affect one organ more prominently than others.
Managing the Oral Manifestations of Alagille Syndrome
Oral manifestations of Alagille syndrome, such as the greenish discoloration of the teeth, can be psychologically distressing to patients.
Patient Perspectives
A Mother Wrestles With How to Discipline Her Son With ALGS
When it comes to my son, who lives with Alagille syndrome (ALGS), it is challenging for me to discipline him.
My Daughter’s ‘Mild’ Alagille Syndrome Is Still ALGS
Once my son was diagnosed with Alagille syndrome (ALGS), we realized that my daughter’s genetic test was likely to confirm the JAG mutation for the disease.
When Your Child Has ALGS, Child Care Is No Easy Decision
When you have a child with ALGS it can be hard to take time away to recharge and not feel an overwhelming amount of guilt.
How Supplemental Insurance Can Help With the Costs of ALGS Treatment
After my son was diagnosed with Alagille syndrome (ALGS), we realized how quickly the medical expenses piled up.
ALGS Features
Growth and Nutrition Considerations in Managing Alagille Syndrome
Pediatric gastroenterologist Dr. Henry Lin describes growth, nutritional, and psychosocial considerations for clinicians managing patients with ALGS.
Kidney, Skeletal, Eye, and Vascular Considerations in Managing Alagille Syndrome
Dr. Henry Lin reviews common clinical presentations and management considerations for renal, skeletal, ocular, and vascular involvement in ALGS.
Managing the Clinical Manifestations of ALGS: Hepatic and Cardiac Considerations
Pediatric gastroenterologist Henry Lin, MD, MBA, reviews how the liver and cardiac system are involved in Alagille syndrome.
Relieving the ‘Devastating’ Severe Itching Faced by Patients With Alagille Syndrome
Kristen Baugher knew shortly after giving birth to her daughter, Emmery, that something was wrong. Jaundiced and weak, the baby itched uncontrollably.
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