Latest ALGS News
Case Report: Liver Transplantation in a Pediatric Patient With ALGS and COVID-19
Researchers Develop Health State Vignettes for Alagille Syndrome
Albireo Seeking FDA Approval of ALGS Indication for Odevixibat
Ileal Bile Acid Transport Blockers Shown to Reduce Burden of Alagille Syndrome
Maralixibat Approved in EU to Treat Cholestatic Pruritus in Patients With ALGS
Anomalous Origin of the Pulmonary Arteries in ALGS Underestimated
Unique Variant Found in Select ALGS Cases
Arterial Surgical Technique on an Infant With ALGS
Case Report: Alagille Syndrome Due to De Novo NOTCH2 Mutation
Latest Clinical Trials
- Efficacy and Safety of Odevixibat in Patients With Alagille Syndrome (ASSERT)
- Long-term Safety and Efficacy of Odevixibat in Patients With Alagille Syndrome (ASSERT-EXT)
- A Maralixibat Expanded Access Program for Patients With Cholestatic Pruritus Associated With Alagille Syndrome (ALGS)
- Evaluation of LUM001 in the Reduction of Pruritus in Alagille Syndrome (ITCH)
- Safety and Efficacy Study of LUM001 (Maralixibat) With a Drug Withdrawal Period in Participants With Alagille Syndrome (ALGS) (ICONIC)
Insights
Drug Repurposing: A Novel Strategy for a Deeply Unequal World
The belief driving drug repurposing is that the current drugs that we do have may yet possess therapeutic aspects we aren’t fully aware of.
Case Study: Arterial Stenoses in Alagille Syndrome
Researchers present the case study of a patient who presented with multiple arterial stenoses and was later diagnosed with Alagille syndrome.
The Vital Importance of Liver Transplantation in Patients With ALGS
Liver transplantation is often urgently required in patients with Alagille syndrome and end-stage liver disease.
Hepatocellular Carcinoma From a Background of Alagille Syndrome
Patients who are diagnosed with Alagille syndrome early in life may develop hepatocellular carcinoma much later.
Patient Perspectives
Virus Threats Mean Constant Monitoring of Symptoms in My Son’s Battle With ALGS
Stomach viruses can become challenging for those with rare diseases such as Alagille syndrome (ALGS).
The Many Ways ALGS Turns Your Life Upside Down
As a parent of a child with ALGS the doctor appointments, routine visits, and lab work visits can be a lot to manage.
Managing My Son’s Xanthomas Amid Alagille Syndrome
When my son’s liver disease progressed due to Alagille syndrome (ALGS) his xanthomas worsened.
Living With ALGS Means a Relentless Fear of Germs and Viruses
Being the caregiver for someone with Alagille syndrome can come with its own set of challenges and emotions.
ALGS Features
Ambitious NCATS Bespoke Gene Therapy Consortium Targets Ultrarare Diseases
The Bespoke Gene Therapy Consortium (BGTC) is an ambitious public-private partnership that aims to develop gene therapies for ultrarare diseases.
EveryLife Foundation Navigates Complex Issues to Advocate for Rare Disease Patients
The EveryLife Foundation for Rare Diseases pushes a legislative agenda aimed at benefitting the 30 million Americans with a rare disease.
Growth and Nutrition Considerations in Managing Alagille Syndrome
Pediatric gastroenterologist Dr. Henry Lin describes growth, nutritional, and psychosocial considerations for clinicians managing patients with ALGS.
Kidney, Skeletal, Eye, and Vascular Considerations in Managing Alagille Syndrome
Dr. Henry Lin reviews common clinical presentations and management considerations for renal, skeletal, ocular, and vascular involvement in ALGS.
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